Role of TGF-beta on cardiac structural and electrical remodeling

被引:0
|
作者
Ramos-Mondragon, Roberto [1 ]
Galindo, Carlos A. [1 ]
Avila, Guillermo [1 ]
机构
[1] IPN, CINVESTAV, Dept Bioquim, AP 14-740, Mexico City 07000, DF, Mexico
关键词
transforming growth factor; ion channel; cardiac electrophysiology;
D O I
暂无
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The type beta transforming growth factors (TGF-beta s) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-beta affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-beta signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-beta affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-beta on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-beta on cardiac development and disease from structural and electrophysiological points of view.
引用
收藏
页码:1289 / 1300
页数:12
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