GENETIC DIVERSITY OF PLASMODIUM-FALCIPARUM IN A VILLAGE IN EASTERN SUDAN .1. DIVERSITY OF ENZYMES, 2D-PAGE PROTEINS AND ANTIGENS

被引：78
作者：
BABIKER, HA
CREASEY, AM
FENTON, B
BAYOUMI, RAL
ARNOT, DE
WALLIKER, D
机构：
[1] MINIST HLTH SUDAN, MALARIA ADM, KHARTOUM, SUDAN
[2] UNIV KHARTOUM, FAC MED, DEPT BIOCHEM, KHARTOUM, SUDAN
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 85卷 / 05期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0035-9203(91)90347-2
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Twenty-nine Plasmodium falciparum isolates from patients in Asar village, eastern Sudan, were characterized for variation in 18 different genetically controlled characters, including iso-enzymes, proteins detected by two-dimensional polyacrylamide gel electrophoresis and blood-stage antigens. Considerable allelic diversity in the genes determining these characters was detected. Each isolate contained genetically distinct parasites. Fifteen individuals were infected with more than one parasite genotype. The diversity of parasite types is most probably generated by recombination during mosquito transmission of mixed parasite clones.
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收藏
页码：572 / 577
页数：6
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