BLEOMYCIN - A PHARMACOLOGICAL TOOL IN THE STUDY OF THE PATHOGENESIS OF INTERSTITIAL PULMONARY FIBROSIS

被引：63
作者：
LAZO, JS
HOYT, DG
SEBTI, SM
PITT, BR
机构：
[1] Department of Pharmacology, University of Pittsburgh, School of Medicine, Pittsburgh
来源：
PHARMACOLOGY & THERAPEUTICS | 1990年 / 47卷 / 03期
关键词：
D O I：
10.1016/0163-7258(90)90061-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bleomycin is a unique DNA-interactive antitumor agent that has become a popular tool in studies of the pathogenesis of interstitial pulmonary fibrosis. The biochemical and morphological changes seen in the lungs of many species after bleomycin simulate those seen in humans. The availability of these animal models of interstitial pulmonary fibrosis also provides the opportunity to investigate novel pharmacological approaches to preventing this disease. © 1990.
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页码：347 / 358
页数：12
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