BETA-ADRENERGIC REGULATION OF ADENOSINE-3',5'-MONOPHOSPHATE CONCENTRATION IN BRAIN MICROVESSELS

被引：112

作者：

HERBST, TJ ^{[1
]}

RAICHLE, ME ^{[1
]}

FERRENDELLI, JA ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG,ST LOUIS,MO 63110

来源：

SCIENCE | 1979年 / 204卷 / 4390期

关键词：

D O I：

10.1126/science.34879

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Norepinephrine increases the concentration of adenosine 3′,5′-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the β receptors, but the α-adrenergic agonist phenylephrine is without effect; β-adrenergic blockade abolishes the response while αa -adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.

引用

页码：330 / 332

页数：3

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