TIE-1 AND TIE-2 DEFINE ANOTHER CLASS OF PUTATIVE RECEPTOR TYROSINE KINASE GENES EXPRESSED IN EARLY EMBRYONIC VASCULAR SYSTEM

被引:381
作者
SATO, TN
QIN, Y
KOZAK, CA
AUDUS, KL
机构
[1] UNIV KANSAS, DEPT PHARMACEUT CHEM, LAWRENCE, KS 66047 USA
[2] NIAID, MOLEC MICROBIOL LAB, VIRAL BIOL SECT, BETHESDA, MD 20892 USA
关键词
D O I
10.1073/pnas.90.20.9355
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We report the molecular cloning and characterization of two structurally related putative receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse chromosome 4. Both tie-1 and tie-2 encode receptor proteins possessing unique multiple extracellular domains: two immunoglobulin-like loop domains flanking three epidermal growth factor repeats followed by three fibronectin-type III repeats. Both genes are expressed in early embryonic vascular system and in maternal decidual vascular endothelial cells, where the vasculature undergoes an active angiogenesis. tie-2, but not tie-1, expression was also detected in extraembryonic mesoderm of the amnion. tie-1, but not tie-2, is expressed in an acute myelogenic cell line in vitro. tie-1 and tie-2 may form another class within the receptor tyrosine kinase gene family, and further characterization of these genes and identification of their putative ligands should define the nature of the signal-transduction cascades underlying early vascular system development, as well as their differential roles in mesodermal, cells of the amniotic and myeloid lineages.
引用
收藏
页码:9355 / 9358
页数:4
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