A MOLECULAR CLIP THAT BINDS AROMATIC GUESTS BY AN INDUCED-FIT MECHANISM

被引：56
|
作者：
SIJBESMA, RP
WIJMENGA, SS
NOLTE, RJM
机构：
[1] CATHOLIC UNIV NIJMEGEN,NSR CTR,DEPT ORGAN CHEM,6525 ED NIJMEGEN,NETHERLANDS
[2] CATHOLIC UNIV NIJMEGEN,NSR CTR,NATL HF NMR FACIL,6525 ED NIJMEGEN,NETHERLANDS
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 25期
关键词：
D O I：
10.1021/ja00051a013
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The conformational behavior and binding properties of a novel molecular receptor consisting of a diphenylglycoluril unit flanked by two 2,7-disubstituted naphthalene rings is described. The molecule appears in three conformations. These conformations differ in the way that the naphthalene rings are oriented with respect to the two phenyl groups on the concave side of the glycoluril moiety, viz. anti-anti, syn-anti, and syn-syn. The receptor is able to change from one conformation to another by flipping the naphthalene walls. The mechanism and the rate constants for this process were determined by 2D EXSY NMR techniques. One of the three conformations contains a cavity, within which aromatic guest molecules of appropriate size can be bound selectively.
引用
收藏
页码：9807 / 9813
页数：7
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