FAMILIAL INCREASED SERUM INTESTINAL ALKALINE-PHOSPHATASE - A NEW VARIANT ASSOCIATED WITH GILBERTS SYNDROME

被引：6
作者：
LIEVERSE, AG
VANESSEN, GG
BEUKEVELD, GJJ
GAZENDAM, J
DOMPELING, EC
TENKATE, LP
VANBELLE, SA
WEITS, J
机构：
[1] STATE UNIV GRONINGEN HOSP,DEPT INTERNAL MED,OOSTERSINGEL 59,9713 EZ GRONINGEN,NETHERLANDS
[2] ROMAN CATHOLIC HOSP,CLIN CHEM LAB,GRONINGEN,NETHERLANDS
[3] ROMAN CATHOLIC HOSP,DEPT MED GENET,GRONINGEN,NETHERLANDS
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1990年 / 43卷 / 02期
关键词：
D O I：
10.1136/jcp.43.2.125
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Investigation of mild, inherited increased serum alkaline phosphatase activity partially combined with Gilbert's syndrome in one family showed, apart from a normal liver fraction, an intestinal iso-enzyme pattern and an extra band in the agar electrophoresis. Analysis by agarose electrophoresis before and after incubation of neuraminidase showed that the extra fraction was an intestinal variant isoenzyme. The precise genetic background of the two disorders in this family could not be determined from the available data. Abnormal activities of (regular) intestinal alkaline phosphatase isoenzyme caused the increase in serum alkaline phosphatase in the absence of disease.
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收藏
页码：125 / 128
页数：4
相关论文
共 24 条
  • [1] ABASSI V, 1984, CLIN PEDIATR, V23, P336
  • [2] BILLING BH, 1987, DISEASES LIVER, P113
  • [3] CROFTON PM, 1982, CRC CRITICAL REV CLI, P161
  • [4] TRANSIENT ELEVATION OF ALKALINE-PHOSPHATASE POSSIBLY RELATED TO TRIMETHOPRIM-SULFAMETHOXAZOLE THERAPY
    DEVITO, GA
    [J]. JOURNAL OF PEDIATRICS, 1982, 100 (06) : 998 - 999
  • [5] DUCOBU J, 1981, LANCET, V1, P1372
  • [6] Gilbert A, 1901, SEM MED PARIS, V21, P241
  • [7] INHERITED ISOLATED HYPERPHOSPHATASEMIA
    KRUSE, K
    [J]. ACTA PAEDIATRICA SCANDINAVICA, 1983, 72 (06): : 833 - 835
  • [8] PERSISTENT ISOLATED HYPERPHOSPHATASEMIA
    LEWIS, JM
    [J]. SOUTHERN MEDICAL JOURNAL, 1987, 80 (06) : 788 - 790
  • [9] FAMILY WITH RAISED SERUM ALKALINE-PHOSPHATASE ACTIVITY IN THE ABSENCE OF DISEASE
    MCEVOY, M
    SKRABANEK, P
    WRIGHT, E
    POWELL, D
    MCDONAGH, B
    [J]. BRITISH MEDICAL JOURNAL, 1981, 282 (6272) : 1272 - 1272
  • [10] MCKUSICK VA, 1988, MENDELIAN INHERITANC
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