TOTAL SYNTHESIS OF THE POLYENE MACROLIDE ANTIBIOTIC ROXATICIN .1. SYNTHESIS OF THE POLYOL FRAGMENT OF ROXATICIN USING A 4-CARBON CHAIN EXTENSION STRATEGY

被引：45

作者：

MORI, Y

ASAI, M

OKUMURA, A

FURUKAWA, H

机构：

[1] Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, 468

来源：

TETRAHEDRON | 1995年 / 51卷 / 18期

关键词：

D O I：

10.1016/0040-4020(95)00214-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C11-C26 polyol fragment of roxaticin containing eight chiral centers has been prepared in a reiterative manner using coupling reactions of chiral dithianes and epoxides followed by stereoselective reduction.

引用

页码：5299 / 5314

页数：16

共 15 条

[1] Total synthesis of the polyene macrolide antibiotic roxaticin - I. Synthesis of the polyol fragment of roxaticin using a four-carbon chain extension strategy
Mori, Y.
Asai, M.
Okumura, A.
Furukawa, H.
Thermochimica Acta, 1995, 256 (28):
[2] TOTAL SYNTHESIS OF THE POLYENE MACROLIDE ANTIBIOTIC ROXATICIN .2. TOTAL SYNTHESIS OF ROXATICIN
MORI, Y
ASAI, M
KAWADE, J
FURUKAWA, H
TETRAHEDRON, 1995, 51 (18) : 5315 - 5330
[3] Total synthesis of the polyene macrolide antibiotic roxaticin - II. Total synthesis of roxaticin
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Asai, M.
Kawade, J.-I.
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Thermochimica Acta, 1995, 256 (28):
[4] TOTAL SYNTHESIS OF THE POLYENE MACROLIDE ROXATICIN
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ASAI, M
KAWADE, J
OKUMURA, A
FURUKAWA, H
TETRAHEDRON LETTERS, 1994, 35 (35) : 6503 - 6506
[5] SYNTHESIS OF EXTENDED 1,3-POLYOLS USING 4-CARBON UNITS - AN APPROACH TO THE CONSTRUCTION OF THE POLYOL FRAGMENT OF ROXATICIN
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HETEROCYCLES, 1992, 34 (07) : 1281 - 1284
[6] An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397
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TETRAHEDRON LETTERS, 2009, 50 (26) : 3530 - 3533
[7] Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes
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Raja, Aruna
Sasse, Florenz
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ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11 (13) : 2116 - 2139
[8] APPLICATION OF THE 2-DIRECTIONAL CHAIN SYNTHESIS STRATEGY TO THE 1ST STEREOCHEMICAL ASSIGNMENT OF STRUCTURE TO MEMBERS OF THE SKIPPED-POLYOL POLYENE MACROLIDE CLASS - MYCOTICIN-A AND MYCOTICIN-B
SCHREIBER, SL
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (26) : 8120 - 8122
[9] TOTAL SYNTHESIS OF THYMOSIN-BETA-4 .1. CONVENTIONAL SYNTHESIS OF THE FRAGMENT [11-19] OF THYMOSIN-BETA-4
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LIEBIGS ANNALEN DER CHEMIE, 1991, (12): : 1251 - 1257
[10] TOTAL SYNTHESIS OF BRANCHED-CHAIN HIGHER-CARBON SUGARS - 1ST SYNTHESIS OF CALDOSE, CALDITOL AND 4-DEOXYCALDITOL STEREOISOMERS
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