EFFECTS OF FISH OIL RICH IN EICOSAPENTAENOIC ACID ON FOCAL GLOMERULOSCLEROSIS OF ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS

被引：6
作者：
WASHIO, M
NANISHI, F
ONOYAMA, K
OKUDA, S
FUJISHIMA, M
机构：
[1] Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka
来源：
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1993年 / 53卷 / 01期
关键词：
D O I：
10.1016/S0011-393X(05)80153-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of fish oil rich in eicosapentaenoic acid (EPA) and those of purified EPA on the progression of focal glomerulosclerosis were investigated in adriamycin (ADR)-injected rats, a model of progressive chronic renal failure. Fish oil and purified EPA were administered through a gastric tube 1 week after the ADR injections. When compared with the control rats (ADR-CON), total cholesterol was significantly lower in the rats receiving fish oil (ADR-FO) or purified EPA (ADR-EPA) at week 8 (P < 0.05). At week 16, urinary protein excretion, serum creatinine elevation, and glomerulosclerosis were ameliorated in the ADR-FO and ADR-EPA groups but not in the ADR-CON group. Fish oil and purified EPA appear to be potent agents in preventing focal glomerulosclerosis.
引用
收藏
页码：35 / 41
页数：7
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