MODULATORY EFFECT OF PLASMINOGEN ON NMDA-INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM-CONCENTRATION IN RAT CULTURED HIPPOCAMPAL-NEURONS

被引：25
|
作者：
INOUE, K [1 ]
KOIZUMI, S [1 ]
NAKAJIMA, K [1 ]
HAMANOUE, M [1 ]
KOHSAKA, S [1 ]
机构：
[1] NATL INST NEUROSCI,DEPT NEUROCHEM,KODAIRA,TOKYO 187,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 179卷 / 1-2期
关键词：
PLASMINOGEN; NMDA; HIPPOCAMPUS; CA2+;
D O I：
10.1016/0304-3940(94)90941-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of plasminogen on the intracellular Ca2+ concentration ([Ca](i)) was examined in cultured rat hippocampal neurons. Plasminogen (100 nM) did not increase [Ca](i) in the presence of tetrodotoxin (TTX, 3 mu M) but increased [Ca](i) in the absence of TTX. In all the cells which responded to plasminogen (100 nM), NMDA (5 mu M) also increased [Ca](i) in the presence of TTX. Furthermore, plasminogen (100 nM) enhanced the NMDA-evoked [Ca](i) increase, and the potentiation by plasminogen was blocked by an NMDA receptor blocker, 2-amino-phosphonovalerate (APV). These data suggest that plasminogen enhances glutamate-evoked [Ca](i) increase through modulation of NMDA receptor in hippocampal neurons.
引用
收藏
页码：87 / 90
页数：4
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