DICALCIUM PHOSPHATE DIHYDRATE AND ANHYDROUS DICALCIUM PHOSPHATE FOR DIRECT COMPRESSION - A COMPARATIVE-STUDY

被引：30

作者：

DOLDAN, C ^{[1
]}

SOUTO, C ^{[1
]}

CONCHEIRO, A ^{[1
]}

MARTINEZPACHECO, R ^{[1
]}

GOMEZAMOZA, JL ^{[1
]}

机构：

[1] UNIV SANTIAGO,FAC FARM,DEPT FARMACOL FARM & TECNOL FARMACEUT,E-15706 SANTIAGO,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 124卷 / 01期

关键词：

DICALCIUM PHOSPHATE DIHYDRATE; ANHYDROUS DICALCIUM PHOSPHATE; DIRECT COMPRESSION; FLOW PROPERTIES; COMPRESSION PROPERTIES; MICROSTRUCTURE;

D O I：

10.1016/0378-5173(95)00077-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dicalcium phosphate dihydrate (Emcompress) and anhydrous dicalcium phosphate (Anhydrous Emcompress) for direct compression were compared as regards particle size distribution and flow properties, which were found to be similar for the two products, and microporous structure and compression properties, which differed markedly. Specifically, intraparticular porosity and mean yield pressure of the anhydrous product were greater than for the dihydrate. Several properties of compacts of both products were also compared: compacts of the anhydrous phosphate disintegrated much more rapidly in distilled water than those of the dihydrate, which was attributed to the greater porosity of the former compacts.

引用

页码：69 / 74

页数：6

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