SERENDIPITOUS SYNTHESIS OF A CYCLOPROPANE-CONTAINING TAXOL ANALOG VIA ANCHIMERIC PARTICIPATION OF AN UNACTIVATED ANGULAR METHYL-GROUP

被引：47

作者：

CHEN, SH

HUANG, S

WEI, JM

FARINA, V

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492-7660, 5 Research Parkway

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 17期

关键词：

D O I：

10.1021/jo00069a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of a 7-epi taxol derivative with DAST in dichloromethane led to an unexpected reaction involving participation of the C-19 methyl group and clean formation of a cyclopropane ring.

引用

页码：4520 / 4521

页数：2

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