OLIGONUCLEOTIDES DERIVED FROM 5-(1-PROPYNYL)-2'-O-ALLYL-URIDINE AND 5-(1-PROPYNYL)-2'-O-ALLYL-CYTIDINE - SYNTHESIS AND RNA DUPLEX FORMATION

被引：53

作者：

FROEHLER, BC

JONES, RJ

CAO, XD

TERHORST, TJ

机构：

[1] Gilead Sciences Inc., Foster City, CA 94404

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77476-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protected nucleoside analogs of 5-(1-propynyl)-2'-O-allyl-uridine and 5-(1-propynyl)-2'-O-allyl-cytidine are described. Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA.

引用

页码：1003 / 1006

页数：4

共 16 条

[1] ANTISENSE PROBES TARGETED TO AN INTERNAL DOMAIN IN U2 SNRNP SPECIFICALLY INHIBIT THE 2(D STEP OF PRE-MESSENGER-RNA SPLICING [J].

BARABINO, SML ;

SPROAT, BS ;

LAMOND, AI .

NUCLEIC ACIDS RESEARCH, 1992, 20 (17) :4457-4464

[2] MAPPING U2 SNRNP - PRE-MESSENGER RNA INTERACTIONS USING BIOTINYLATED OLIGONUCLEOTIDES MADE OF 2'-OME RNA [J].

BARABINO, SML ;

SPROAT, BS ;

RYDER, U ;

BLENCOWE, BJ ;

LAMOND, AI .

EMBO JOURNAL, 1989, 8 (13) :4171-4178

[3] ANTISENSE PROBING OF THE HUMAN U4/U6 SNRNP WITH BIOTINYLATED 2'-OME RNA OLIGONUCLEOTIDES [J].

BLENCOWE, BJ ;

SPROAT, BS ;

RYDER, U ;

BARABINO, S ;

LAMOND, AI .

CELL, 1989, 59 (03) :531-539

[4] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF OLIGODEOXYRIBONUCLEOTIDE BASE COMPOSITION [J].

EADIE, JS ;

MCBRIDE, LJ ;

EFCAVITCH, JW ;

HOFF, LB ;

CATHCART, R .

ANALYTICAL BIOCHEMISTRY, 1987, 165 (02) :442-447

[5] OLIGODEOXYNUCLEOTIDES CONTAINING C-5 PROPYNE ANALOGS OF 2'-DEOXYURIDINE AND 2'-DEOXYCYTIDINE [J].

FROEHLER, BC ;

WADWANI, S ;

TERHORST, TJ ;

GERRARD, SR .

TETRAHEDRON LETTERS, 1992, 33 (37) :5307-5310

[6] SYNTHESIS OF DNA VIA DEOXYNUCLEOSIDE H-PHOSPHONATE INTERMEDIATES [J].

FROEHLER, BC ;

NG, PG ;

MATTEUCCI, MD .

NUCLEIC ACIDS RESEARCH, 1986, 14 (13) :5399-5407

[7] DIALKYLFORMAMIDINES - DEPURINATION RESISTANT N-6-PROTECTING GROUP FOR DEOXYADENOSINE [J].

FROEHLER, BC ;

MATTEUCCI, MD .

NUCLEIC ACIDS RESEARCH, 1983, 11 (22) :8031-8036

[8] Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties [J].

Goodchild, John .

BIOCONJUGATE CHEMISTRY, 1990, 1 (03) :165-187

[9] PALLADIUM-CATALYZED SYNTHESIS OF ALKYNYLAMINO NUCLEOSIDES - A UNIVERSAL LINKER FOR NUCLEIC-ACIDS [J].

HOBBS, FW .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (14) :3420-3422

[10] SEQUENCE-DEPENDENT HYDROLYSIS OF RNA USING MODIFIED OLIGONUCLEOTIDE SPLINTS AND RNASE H [J].

INOUE, H ;

HAYASE, Y ;

IWAI, S ;

OHTSUKA, E .

FEBS LETTERS, 1987, 215 (02) :327-330

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