THE ROLE OF IRON IN BETA-AMYLOID TOXICITY

被引：152

作者：

SCHUBERT, D ^{[1
]}

CHEVION, M ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,IL-91120 JERUSALEM,ISRAEL

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 216卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction Or by virtue of hypervalent iron compounds. It is shown here that iron facilitates A beta toxicity to cultured cells. (C) 1995 Academic Press, Inc.

引用

页码：702 / 707

页数：6

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