THE EFFECT OF ADENOSINE ON COCHLEAR POTENTIALS IN THE GUINEA-PIG

被引：0

作者：

NARIO, K ^{[1
]}

KITANO, I ^{[1
]}

MORI, N ^{[1
]}

MATSUNAGA, T ^{[1
]}

机构：

[1] KAGAWA MED SCH,DEPT OTOLARYNGOL,KAGAWA 76107,JAPAN

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1994年 / 251卷 / 07期

关键词：

COCHLEAR POTENTIALS; NEUROMODULATION; ADENOSINE;

D O I：

暂无

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The effect of adenosine on cochlear potentials was examined in the guinea pig. Perilymphatic perfusion with 10(-4) M adenosine produced a significant decrease in the amplitudes of cochlear microphonics, negative summating potential (-SP) and compound action potential (CAP) and significant prolongation of N1 latency with no change in the endocochlear potential. The decreases in the amplitudes of -SP and CAP caused by adenosine were dose-dependent. Perilymphatic perfusion with an inactive analogue, 8-bromoadenosine, produced no changes in the cochlear potentials. The A1-receptor agonist, 2-chloroadenosine, produced a similar change in cochlear potentials to adenosine, while no changes were produced by the A2-receptor agonist ,5'-(N-ethylcarboxamido)-adenosine. These results suggest that adenosine may have a medulatory function through an A1 receptor in the cochlea.

引用

页码：428 / 433

页数：6

共 23 条

[1] ADENOSINERGIC INHIBITION IN HIPPOCAMPUS IS MEDIATED BY ADENOSINE-A1-RECEPTORS VERY SIMILAR TO THOSE OF PERIPHERAL-TISSUES [J].