CYTOGENETIC MONITORING OF FISHERMEN WITH ENVIRONMENTAL MERCURY EXPOSURE

被引：49
作者：
FRANCHI, E [1 ]
LOPRIENO, G [1 ]
BALLARDIN, M [1 ]
PETROZZI, L [1 ]
MIGLIORE, L [1 ]
机构：
[1] UNIV PISA,DIPARTIMENTO SCI AMBIENTE & TERR,I-56100 PISA,ITALY
来源：
MUTATION RESEARCH | 1994年 / 320卷 / 1-2期
关键词：
MONITORING; HUMAN LYMPHOCYTE MICRONUCLEUS ASSAY; MERCURY;
D O I：
10.1016/0165-1218(94)90056-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Due to high mercury levels in many Mediterranean aquatic organisms, people who live in this area and consume large amounts of seafood are exposed to a toxicological hazard. A group of 51 fishermen exposed to mercury through eating contaminated seafood from the northern Tyrrhenian Sea underwent cytogenetic monitoring. This work is part of a research project consisting of the evaluation of micronuclei (MN), chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in peripheral blood lymphocytes. Here we present data on mercury levels in blood and on micronucleus frequencies in peripheral blood lymphocytes of fishermen. The range of mercury concentrations in blood was 10.08-304.11 ng/g fresh weight, the average was 88.97 +/- 54.09 ng/g. Micronucleus frequency was defined with at least 2000 binucleated cells scored for each person; the average was 8.74 +/- 2.56 expressed on 1000 binucleated cells. A statistical correlation was found between MN frequency and total mercury concentration in blood (p = 0.00041, r = 0.674), as well as between MN frequency and age (p = 0.017). No other parameters taken into account correlated with MN frequency.
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页码：23 / 29
页数：7
相关论文
共 29 条
  • [11] MUTAGENICITY AND TERATOGENICITY OF MERCURY-COMPOUNDS
    LEONARD, A
    JACQUET, P
    LAUWERYS, RR
    [J]. MUTATION RESEARCH, 1983, 114 (01): : 1 - 18
  • [12] HEAVY-METALS IN ORGANISMS FROM THE NORTHERN TYRRHENIAN SEA
    LEONZIO, C
    BACCI, E
    FOCARDI, S
    RENZONI, A
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 1981, 20 (02) : 131 - 146
  • [13] CYTOGENETIC EXAMINATION OF LEUKOCYTES OF WORKERS EXPOSED TO MERCURY-VAPOR
    MABILLE, V
    ROELS, H
    JACQUET, P
    LEONARD, A
    LAUWERYS, R
    [J]. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1984, 53 (03) : 257 - 260
  • [14] MICRONUCLEI IN LYMPHOCYTES OF YOUNG-PATIENTS UNDER ANTILEUKEMIC THERAPY
    MIGLIORE, L
    GUIDOTTI, P
    FAVRE, C
    NARDI, M
    SESSA, MR
    BRUNORI, E
    [J]. MUTATION RESEARCH, 1991, 263 (04): : 243 - 248
  • [15] GENETIC-EFFECTS OF METHYLMERCURY IN HUMAN-CHROMOSOMES .1. A CYTOGENETIC STUDY OF PEOPLE EXPOSED THROUGH EATING CONTAMINATED FISH
    MONSALVE, MV
    CHIAPPE, C
    [J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1987, 10 (04) : 367 - 376
  • [16] CHROMOSOME-ABERRATIONS INDUCED BY OCCUPATIONAL EXPOSURE TO MERCURY
    POPESCU, HI
    NEGRU, L
    LANCRANJAN, I
    [J]. ARCHIVES OF ENVIRONMENTAL HEALTH, 1979, 34 (06): : 461 - 463
  • [17] Renzoni A., 1979, Journees d'Etudes sur les Pollutions Marines en Mediterranee, V4, P255
  • [18] RENZONI A, 1987, 6TH P INT C HEAV MET, P80
  • [19] ELEVATION OF MERCURY IN HUMAN-BLOOD FROM CONTROLLED CHRONIC INGESTION OF METHYLMERCURY IN FISH
    SHERLOCK, J
    HISLOP, J
    NEWTON, D
    TOPPING, G
    WHITTLE, K
    [J]. HUMAN TOXICOLOGY, 1984, 3 (02): : 117 - 131
  • [20] METHYLMERCURY-INDUCED CHROMOSOME DAMAGE IN MAN
    SKERFVING, S
    HANSSON, K
    MANGS, C
    LINDSTEN, J
    RYMAN, N
    [J]. ENVIRONMENTAL RESEARCH, 1974, 7 (01) : 83 - 98
123