CYTOGENETIC MONITORING OF FISHERMEN WITH ENVIRONMENTAL MERCURY EXPOSURE

被引：49

作者：

FRANCHI, E ^{[1
]}

LOPRIENO, G ^{[1
]}

BALLARDIN, M ^{[1
]}

PETROZZI, L ^{[1
]}

MIGLIORE, L ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO SCI AMBIENTE & TERR,I-56100 PISA,ITALY

来源：

MUTATION RESEARCH | 1994年 / 320卷 / 1-2期

关键词：

MONITORING; HUMAN LYMPHOCYTE MICRONUCLEUS ASSAY; MERCURY;

D O I：

10.1016/0165-1218(94)90056-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Due to high mercury levels in many Mediterranean aquatic organisms, people who live in this area and consume large amounts of seafood are exposed to a toxicological hazard. A group of 51 fishermen exposed to mercury through eating contaminated seafood from the northern Tyrrhenian Sea underwent cytogenetic monitoring. This work is part of a research project consisting of the evaluation of micronuclei (MN), chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in peripheral blood lymphocytes. Here we present data on mercury levels in blood and on micronucleus frequencies in peripheral blood lymphocytes of fishermen. The range of mercury concentrations in blood was 10.08-304.11 ng/g fresh weight, the average was 88.97 +/- 54.09 ng/g. Micronucleus frequency was defined with at least 2000 binucleated cells scored for each person; the average was 8.74 +/- 2.56 expressed on 1000 binucleated cells. A statistical correlation was found between MN frequency and total mercury concentration in blood (p = 0.00041, r = 0.674), as well as between MN frequency and age (p = 0.017). No other parameters taken into account correlated with MN frequency.

引用

页码：23 / 29

页数：7

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