CHROMOSOME-ABERRATIONS (CA), SISTER-CHROMATID EXCHANGES (SCE) AND MITOGEN-INDUCED BLASTOGENESIS IN CULTURED PERIPHERAL LYMPHOCYTES FROM 48 CONTROL INDIVIDUALS SAMPLED 8 TIMES OVER 2 YEARS

被引:44
作者
ANDERSON, D
FRANCIS, AJ
GODBERT, P
JENKINSON, PC
BUTTERWORTH, KR
机构
[1] BIBRA Toxicology International, Carshalton,, Surrey Surrey SM5 4DS, Woodmansterne Road
来源
MUTATION RESEARCH | 1991年 / 250卷 / 1-2期
关键词
CHROMOSOME ABERRATIONS; SISTER-CHROMATID EXCHANGES; BLASTOGENESIS; MITOGEN-INDUCED; PERIPHERAL LYMPHOCYTES; CULTURED;
D O I
10.1016/0027-5107(91)90203-Z
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Confidence in the measurement of positive effects determined by monitoring of environmentally or occupationally exposed individuals can be enhanced by a knowledge of the normal variability in these endpoints in the general population. Confounding effects can be determined and study interpretation improved by correlation of this variability with various lifestyle factors such as sex and age of donor, smoking and drinking habits, viral infections, exposure to diagnostic X-rays, etc. 8 blood samples were taken from each of 24 male and 24 female volunteers over a period of 2 years. Questionnaires pertaining to lifestyle were completed at the time of each sampling. Whole blood was cultured and slides prepared for CA or SCE analysis. Separated mononuclear cells were cultured with a range of phytohaemagglutinin concentrations and the maximum level of mitogen-induced blastogenesis was determined by measurement of [H-3]thymidine uptake. There was a significant effect of both year and season of sampling for all 3 endpoints. No significant effects in any of the 3 endpoints were found with respect to sex or age of donor nor any of the other lifestyle factors, although SCE frequency and mitogen-induced blastogenesis were nearly always higher in females than males. These results point to the need for concurrent sampling of controls with exposed populations.
引用
收藏
页码:467 / 476
页数:10
相关论文
共 27 条
  • [1] CHROMOSOME-ABERRATIONS, MITOGEN-INDUCED BLASTOGENESIS AND PROLIFERATIVE RATE INDEX IN PERIPHERAL LYMPHOCYTES FROM 106 CONTROL INDIVIDUALS OF THE UK POPULATION
    ANDERSON, D
    JENKINSON, PC
    DEWDNEY, RS
    FRANCIS, AJ
    GODBERT, P
    BUTTERWORTH, KR
    [J]. MUTATION RESEARCH, 1988, 204 (03): : 407 - 420
  • [2] CHROMOSOMAL ANALYSES IN VINYL-CHLORIDE EXPOSED WORKERS - RESULTS FROM ANALYSIS 18 AND 42 MONTHS AFTER AN INITIAL SAMPLING
    ANDERSON, D
    RICHARDSON, CR
    WEIGHT, TM
    PURCHASE, IFH
    ADAMS, WGF
    [J]. MUTATION RESEARCH, 1980, 79 (02): : 151 - 162
  • [3] ANDERSON DA, 1986, MONITORING OCCUPATIO, P39
  • [4] CYTOGENETIC ROGUE CELLS - WHAT IS THEIR FREQUENCY, ORIGIN, AND EVOLUTIONARY SIGNIFICANCE
    AWA, AA
    NEEL, JV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) : 1021 - 1025
  • [5] CHROMOSOMAL ABERRATION AND SISTER-CHROMATID EXCHANGE FREQUENCIES IN PERIPHERAL-BLOOD LYMPHOCYTES OF A LARGE HUMAN-POPULATION SAMPLE .2. EXTENSION OF AGE RANGE
    BENDER, MA
    PRESTON, RJ
    LEONARD, RC
    PYATT, BE
    GOOCH, PC
    [J]. MUTATION RESEARCH, 1989, 212 (02): : 149 - 154
  • [6] CURRENT STATUS OF CYTOGENETIC PROCEDURES TO DETECT AND QUANTIFY PREVIOUS EXPOSURES TO RADIATION
    BENDER, MA
    AWA, AA
    BROOKS, AL
    EVANS, HJ
    GROER, PG
    LITTLEFIELD, LG
    PEREIRA, C
    PRESTON, RJ
    WACHHOLZ, BW
    [J]. MUTATION RESEARCH, 1988, 196 (02): : 103 - 159
  • [7] CYTOGENETIC MONITORING OF HOSPITAL WORKERS EXPOSED TO LOW-LEVEL IONIZING-RADIATION
    BIGATTI, P
    LAMBERTI, L
    ARDITO, G
    ARMELLINO, F
    [J]. MUTATION RESEARCH, 1988, 204 (02): : 343 - 347
  • [8] CAMPBELL MJ, 1980, CLIN EXP IMMUNOL, V39, P176
  • [9] CONSIDERATIONS FOR POPULATION MONITORING USING CYTOGENETIC TECHNIQUES
    CARRANO, AV
    NATARAJAN, AT
    [J]. MUTATION RESEARCH, 1988, 204 (03): : 379 - 406
  • [10] VARIATION IN SISTER-CHROMATID EXCHANGE AMONG 106 MEMBERS OF THE GENERAL UK POPULATION
    DEWDNEY, RS
    LOVELL, DP
    JENKINSON, PC
    ANDERSON, D
    [J]. MUTATION RESEARCH, 1986, 171 (01): : 43 - 51