EFFECT OF PHENAMINE ON ULTRASTRUCTURAL-CHANGES IN VARIOUS RAT-BRAIN REGIONS

In response to phenamine (amphetamine), the neurons in the sensomotor cortex, hippocampus, central gray matter, and cerebellum react to yield fringy vesicles associated with receptor-mediated endocytosis. The drug causes a powerful and prolonged activation of energy apparatus and protein synthesis, followed by impairment of neuronal plastic processes. Phenamine promotes the establishment of direct communications between the nerve cells and perineuronal satellites whose occurrence mechanism is related to lysosomal activation. Phenamine-induced stimulation of synaptic and non-synaptic interactions between the neurons is characterized by the distinctive pattern -no impairments in the communication apparatus, ensuring steady-state performance of neuron ensembles.