EFFECT OF PHENAMINE ON ULTRASTRUCTURAL-CHANGES IN VARIOUS RAT-BRAIN REGIONS

被引：0

作者：

KARKISHCHENKO, NN ^{[1
]}

MAKLYAKOV, YS ^{[1
]}

BARDAKHCHYAN, EA ^{[1
]}

KHARLANOVA, NG ^{[1
]}

机构：

[1] ROSTOV DON ANTIPLAGUE RES INST,ROSTOV,USSR

来源：

KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1991年 / 25卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In response to phenamine (amphetamine), the neurons in the sensomotor cortex, hippocampus, central gray matter, and cerebellum react to yield fringy vesicles associated with receptor-mediated endocytosis. The drug causes a powerful and prolonged activation of energy apparatus and protein synthesis, followed by impairment of neuronal plastic processes. Phenamine promotes the establishment of direct communications between the nerve cells and perineuronal satellites whose occurrence mechanism is related to lysosomal activation. Phenamine-induced stimulation of synaptic and non-synaptic interactions between the neurons is characterized by the distinctive pattern -no impairments in the communication apparatus, ensuring steady-state performance of neuron ensembles.

引用

页码：10 / 13

页数：4

共 11 条

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[6] KARKISHCHENKO N N, 1990, Byulleten' Eksperimental'noi Biologii i Meditsiny, V109, P86
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[8] POPOVA EN, 1976, MORFOLOGIYA PRISPOSO
[9] POVILAITITE P E, 1986, Tsitologiya i Genetika, V20, P323
[10] SHMIDT R, 1985, FIZIOLOGIYA CHELOVEK, V1

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