CP-93,129, A POTENT AND SELECTIVE 5-HT1B RECEPTOR AGONIST BLOCKS NEUROGENIC PLASMA EXTRAVASATION WITHIN RAT BUT NOT GUINEA-PIG DURA-MATER

被引：40

作者：

MATSUBARA, T ^{[1
]}

MOSKOWITZ, MA ^{[1
]}

BYUN, B ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,NEUROSURG & NEUROL SERV,BOSTON,MA 02114

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 104卷 / 01期

关键词：

5-HT1B RECEPTORS; 5-HT1D RECEPTORS; MIGRAINE; DURA MATER; NEUROGENIC INFLAMMATION;

D O I：

10.1111/j.1476-5381.1991.tb12374.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pretreatment with CP-93,129 blocked plasma extravasation in rat dura mater induced by electrical trigeminal ganglion stimulation when administered at greater-than-or-equal-to 140 nmol kg-1, i.v. but did not affect plasma leakage in guinea-pig at 460 or 1400 nmol kg-1. Sumatriptan, a 5-HT1D-like receptor agonist, blocked plasma extravasation in the guinea-pig model when administered at 7 nmol kg-1. In as much as CP-93,129 binds with micromolar affinities to 5-HT1A, 5-HT1c, 5-HT1D, and 5-HT2 recognition sites, and with nanomolar affinity to the 5-HT1B receptor subtype, blockade of plasma extravasation in the rat dura mater may be mediated by 5-HT1B receptors whereas the 5-HT1D receptor may be more relevant to the guinea-pig.

引用

页码：3 / 4

页数：2

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