PHOSPHORYLATION IN-VITRO OF GLIAL FIBRILLARY ACIDIC PROTEIN IS INCREASED IN RAT HIPPOCAMPUS BY ADMINISTRATION OF 2,5-HEXANEDIONE

被引：2

作者：

PEREIRA, ME ^{[1
]}

GONCALVES, CA ^{[1
]}

RODNIGHT, R ^{[1
]}

机构：

[1] UFRGS CTR,INST BIOCIENCIAS,DEPT BIOQUIM,BR-90046900 PORTO ALEGRE,RS,BRAZIL

来源：

BRAIN RESEARCH | 1994年 / 656卷 / 02期

关键词：

GLIAL FIBRILLARY ACIDIC PROTEIN; GFAP; 2,5-HEXANEDIONE; HIPPOCAMPUS; PROTEIN PHOSPHORYLATION; RAT;

D O I：

10.1016/0006-8993(94)91488-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were treated with 2,5-hexanedione (2,5-HD) daily for 30 days. Hippocampal microslices were then incubated with [P-32]phosphate and the in vitro rate of phosphorylation and the immune-content of glial acidic fibrillary protein (GFAP) were measured. Exposure to 2,5-HD decreased by 25% the immune-content of GFAP and increased by 35% its rate of phosphorylation, resulting in an increase of 88% in the ratio phosphorylation rate/immuno-content for this protein.

引用

页码：417 / 419

页数：3

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