COMPARISON OF EFFICACY OF 2 OXIMES (HI-6 AND OBIDOXIME) IN SOMAN POISONING IN RATS

被引：40

作者：

KASSA, J

机构：

[1] Purkyně Military Medical Academy, 502 60 Hradec Králové

来源：

TOXICOLOGY | 1995年 / 101卷 / 03期

关键词：

SOMAN; HI-6; OBIDOXIME; ACETYCHOLINESTERASE; CORTICOSTERONE; TYROSINE AMINOTRANSFERASE; RAT;

D O I：

10.1016/0300-483X(95)03091-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The action of HI-6 (1-[[[(4-aminocarbonyl)pyridiniol]methoxy]methyl]-2-[(hydroxyimino)methyl] pyridinium dichloride monohydrate) and obidoxime on soman-induced anticholinesterase and stressogenic effects was studied in rats. HI-6 significantly affected acetylcholinesterase inhibition in erythrocytes, brain and diaphragm and practically eliminated the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine aminotransferase activity, while obidoxime, on the other hand, had very little influence on soman-induced inhibition of acetylcholinesterase activity and the stressogenic effects of soman. These findings support a hypothesis that the effects of HI-6 are not solely due to reactivation of the enzyme. They also demonstrate its importance in the treatment of soman poisoning in rats.

引用

页码：167 / 174

页数：8

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