CEREBROSPINAL-FLUID CONCENTRATION OF NEURON-SPECIFIC ENOLASE IN DIAGNOSIS OF CREUTZFELDT-JAKOB-DISEASE

被引：155
作者：
ZERR, I
BODEMER, M
RACKER, S
GROSCHE, S
POSER, S
KRETZSCHMAR, HA
WEBER, T
机构：
[1] UNIV GOTTINGEN,NEUROL KLIN & POLIKLIN,D-37075 GOTTINGEN,GERMANY
[2] UNIV GOTTINGEN,INST NEUROPATHOL,D-37075 GOTTINGEN,GERMANY
来源：
LANCET | 1995年 / 345卷 / 8965期
关键词：
D O I：
10.1016/S0140-6736(95)90118-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neuron-specific enolase (NSE) is among the biochemical markers in cerebrospinal fluid reported to be useful in the differential diagnosis of Creutzfeldt-Jakob disease from other dementing illnesses. In a group of 58 patients definite and Creutzfeldt-Jakob disease, with probable NSE concentrations (median 94 . 0, interquartile range 256 ng/mL) were significantly higher (p<0 . 001) than in 26 control patients (9 . 5, 15 . 5 ng/mL). At a cut-off of 35 ng/mL an optimum sensitivity of 80% with a specificity of 92% for the diagnosis of Creutzfeldt-Jakob disease by NSE in cerebrospinal fluid was obtained.
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页码：1609 / 1610
页数：2
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