Comparison of effect-site concentration of remifentanil for tracheal intubation with the lightwand and laryngoscopy during propofol target-controlled infusion

被引：4
作者：
Kim, Jin-Soo [1 ]
Kim, Dae-Hee [1 ]
Min, Sang-Kee [1 ]
Kim, Kyung-Mi [1 ]
Kim, Jong-Yeop [1 ]
机构：
[1] Ajou Univ, Sch Med, Dept Anesthesiol & Pain Med, San 5,Wonchon Dong, Suwon 443721, South Korea
来源：
KOREAN JOURNAL OF ANESTHESIOLOGY | 2011年 / 60卷 / 06期
关键词：
Intubation; Lightwand; Propofol; Remifentanil; Target-controlled infusion;
D O I：
10.4097/kjae.2011.60.6.393
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Background: Target-controlled infusion (TCI) of propofol and remifentanil can provide satisfactory intubating conditions without a neuromuscular blocking agent. We compared the effect-site concentration of remifentanil required for intubation with the lightwand and the Macintosh laryngoscope during propofol TCI without a neuromuscular blocking agent in adult patients. Methods: Forty-nine patients were randomly assigned to the lightwand group (n = 25) or the direct laryngoscope group (n = 24). Anesthesia was induced by propofol TCI with an effect-site concentration of 5.4 mu g/ml. Two minutes after start of propofol TCI, remifentanil was administered at the predetermined effect-site concentration. The effect-site concentration of remifentanil was determined using Dixon's up-and-down method (0.5 ng/ml as a step size). The first patient in each group was tested at 4.5 ng/ml of remifentanil. Tracheal intubation was performed 2 min after the start of remifentanil TCI. Acceptable intubation was defined as an excellent or good intubating conditions. Results: Using a modified Dixon's up and down method, the EC50 +/- SD of remifentanil in the lightwand and laryngoscope groups was 4.75 +/- 0.71 ng/ml and 5.08 +/- 0.52 ng/ml, respectively; there was no statistically significant difference between the groups (P = 0.373). Conclusions: The effect-site concentration of remifentanil for acceptable intubation with the lightwand and Macintosh laryngoscope in 50% of adults did not differ during propofol TCI without a neuromuscular blocking agent.
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页码：393 / 397
页数：5
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