HOST-CELL MACROMOLECULAR-SYNTHESIS AND VIRAL-RNA SYNTHESIS IN RINDERPEST VIRUS-INFECTED CELLS

The syntheses of cellular DNA. RNA and protein were studied in Veto cells infected with Rinderpest virus. The DNA synthesis was inhibited to a significant extent starting from the early period upto the late period after virus infection. The effect on RNA synthesis was negligible in the early period, but it was inhibited in the late period after virus infection. No significant change in protein synthesis was observed during the early and late periods after virus infection. The synthesis of viral RNA was then studied in infected cells after inhibition of cellular RNA synthesis by using Actinomycin D and it was observed that viral RNA synthesis is completed in 48 hours after infection. © 1978, Indian Academy of Sciences. All rights reserved.