SYNTHESIS OF OLIGORIBONUCLEOTIDES .6. 2'-O-ACYL RIBONUCLEOSIDE DERIVATIVES AS INTERMEDIATES IN SYNTHESIS OF DINUCLEOSIDE PHOSPHATES

被引:34
作者
FROMAGEOT, HP
REESE, CB
SULSTON, JE
机构
[1] University Chemical Laboratory, Cambridge, England
关键词
D O I
10.1016/S0040-4020(01)91986-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
N2, O2′, O5′-Tribenzoylguanosine has been obtained as a pure crystalline compound. The di-ribonucleoside phosphates: guanylyl-(3′ → 5′)-uridine[GpU] and cytidylyl-(3′ → 5′)-uridine[CpU] have been prepared in moderate yields by the condensation (in pyridine solution with mesitylenesulphonyl chloride as the condensing agent) between 2′,3′-di-O-acetyluridine 5′-phosphate and, respectively, N2,O2′,O5′-tribenzoylguanosine and N4,O2′,O5′-triacetylcytidine. The GpU was completely digested to guanosine 3′-phosphate and uridine in the presence of pancreatic ribonuclease. © 1968.
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页码:3533 / +
页数:1
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