LACTIMIDOMYCIN, A NEW GLUTARIMIDE GROUP ANTIBIOTIC - PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：78
作者：
SUGAWARA, K
NISHIYAMA, Y
TODA, S
KOMIYAMA, N
HATORI, M
MORIYAMA, T
SAWADA, Y
KAMEI, H
KONISHI, M
OKI, T
机构：
[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku
来源：
JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期
关键词：
D O I：
10.7164/antibiotics.45.1433
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.
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页码：1433 / 1441
页数：9
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