Report on the 56th ASH Annual Meeting, San Francisco, 4-9 December 2014

被引:2
作者
Agazzi, Alberto [1 ]
机构
[1] European Inst Oncol, Hematoncol Div, Milan, Italy
关键词
chimeric antigen receptors; intensive chemotherapy; PD-1; inhibitors; target therapy;
D O I
10.3332/ecancer.2015.514
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The 56th annual ASH (American Society of Haematology) meeting was held in San Francisco (CA). More than 3,000 abstracts were selected for presentation due to the huge amount of information from basic science to clinical experience. The future direction in haematoncology is targeted therapies for most diseases; for instance, anti-PD-1 and CAR-T cells in lymphoproliferative disorders and novel immunomodulatory agents active in the contest of bone marrow milieu in multiple myeloma. On the other hand, in aggressive haematological diseases (AML, ALL), clinical studies demonstrated the feasibility of a more intensive chemotherapy approach in older patients.
引用
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页数:5
相关论文
共 22 条
[1]   Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial [J].
Armand, Philippe ;
Nagler, Arnon ;
Weller, Edie A. ;
Devine, Steven M. ;
Avigan, David E. ;
Chen, Yi-Bin ;
Kaminski, Mark S. ;
Holland, H. Kent ;
Winter, Jane N. ;
Mason, James R. ;
Fay, Joseph W. ;
Rizzieri, David A. ;
Hosing, Chitra M. ;
Ball, Edward D. ;
Uberti, Joseph P. ;
Lazarus, Hillard M. ;
Mapara, Markus Y. ;
Gregory, Stephanie A. ;
Timmerman, John M. ;
Andorsky, David ;
Or, Reuven ;
Waller, Edmund K. ;
Rotem-Yehudar, Rinat ;
Gordon, Leo I. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (33) :4199-4206
[2]   Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia [J].
Burnett, Alan K. ;
Russell, Nigel H. ;
Hills, Robert K. ;
Kell, Jonathan ;
Freeman, Sylvie ;
Kjeldsen, Lars ;
Hunter, Ann E. ;
Yin, John ;
Craddock, Charles F. ;
Dufva, Inge Hoegh ;
Wheatley, Keith ;
Milligan, Donald .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (32) :3924-3931
[3]  
Deschler B, 2006, HAEMATOLOGICA, V91, P1513
[4]  
Dimopoulos M, 2013, BLOOD, V122, P2331, DOI [10.1182/blood-2013-01-481325, DOI 10.1182/BLOOD-2013-01-481325]
[5]   Concurrent Expression Of MYC/BCL2 Protein In Newly Diagnosed DLBCL Is Not Associated With An Inferior Survival Following EPOCH-R Therapy [J].
Dunleavy, Kieron ;
Pittaluga, Stefania ;
Shovlin, Margaret ;
Pack-B, Svetlana ;
Steinberg, Seth M. ;
Lai, Catherine E. ;
Grant, Cliona ;
Hsi, Eric D. ;
Staudt, Louis M. ;
Jaffe, Elaine S. ;
Wilson, Wyndham H. .
BLOOD, 2013, 122 (21)
[6]  
Dutia M, BLOOD, V114, P1679
[7]   Anthracycline Dose Intensification in Acute Myeloid Leukemia [J].
Fernandez, Hugo F. ;
Sun, Zhuoxin ;
Yao, Xiaopan ;
Litzow, Mark R. ;
Luger, Selina M. ;
Paietta, Elisabeth M. ;
Racevskis, Janis ;
Dewald, Gordon W. ;
Ketterling, Rhett P. ;
Bennett, John M. ;
Rowe, Jacob M. ;
Lazarus, Hillard M. ;
Tallman, Martin S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (13) :1249-1259
[8]   Efficacy of growth factors compared to other therapies for low-risk myelodysplastic syndromes [J].
Golshayan, Ali-Reza ;
Jin, Tao ;
Maciejewski, Jaroslaw ;
Fu, Alex Z. ;
Bershadsky, Boris ;
Kattan, Michael W. ;
Kalaycio, Matt E. ;
Sekeres, Mikkael A. .
BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (02) :125-132
[9]   Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia [J].
Gyurkocza, Boglarka ;
Storb, Rainer ;
Storer, Barry E. ;
Chauncey, Thomas R. ;
Lange, Thoralf ;
Shizuru, Judith A. ;
Langston, Amelia A. ;
Pulsipher, Michael A. ;
Bredeson, Christopher N. ;
Maziarz, Richard T. ;
Bruno, Benedetto ;
Petersen, Finn B. ;
Maris, Michael B. ;
Agura, Edward ;
Yeager, Andrew ;
Bethge, Wolfgang ;
Sahebi, Firoozeh ;
Appelbaum, Frederick R. ;
Maloney, David G. ;
Sandmaier, Brenda M. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (17) :2859-2867
[10]   MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma [J].
Horn, Heike ;
Ziepert, Marita ;
Becher, Claudia ;
Barth, Thomas F. E. ;
Bernd, Heinz-Wolfram ;
Feller, Alfred C. ;
Klapper, Wolfram ;
Hummel, Michael ;
Stein, Harald ;
Hansmann, Martin-Leo ;
Schmelter, Christopher ;
Moeller, Peter ;
Cogliatti, Sergio ;
Pfreundschuh, Michael ;
Schmitz, Norbert ;
Truemper, Lorenz ;
Siebert, Reiner ;
Loeffler, Markus ;
Rosenwald, Andreas ;
Ott, German .
BLOOD, 2013, 121 (12) :2253-2263