INTERLEUKIN-10 INHIBITS ENDOTOXIN-INDUCED TISSUE FACTOR MESSENGER-RNA PRODUCTION BY HUMAN MONOCYTES

被引：50

作者：

RAMANI, M ^{[1
]}

OLLIVIER, V ^{[1
]}

KHECHAI, F ^{[1
]}

VU, T ^{[1
]}

TERNISIEN, C ^{[1
]}

BRIDEY, F ^{[1
]}

DEPROST, D ^{[1
]}

机构：

[1] CHU XAVIER BICHAT,INSERM,U294,46 RUE HENRI HUCHARD,F-75877 PARIS 18,FRANCE

来源：

FEBS LETTERS | 1993年 / 334卷 / 01期

关键词：

TISSUE FACTOR; INTERLEUKIN-10; MONOCYTE; ENDOTOXIN;

D O I：

10.1016/0014-5793(93)81693-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in,septic shock, a condition still associated with a high mortality rate.

引用

页码：114 / 116

页数：3

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