ALTERNATIVE SYNTHESIS OF 6-(3-METHOXYBENZYL)PYRAZIN-2(1H)-ONE - SYNTHESIS OF INDENO[1,2-B]PYRAZIN-2-ONES - CRYSTAL-STRUCTURES OF 5-ACETOXY-1-BENZYL-4-TERT-BUTOXYCARBONYL-6-(3-METHOXYBENZYLIDENE)PIPERAZIN-2-ONE, 1-BENZYL-4-TERT-BUTOXYCARBONYL-7-METHOXY-1,3,4,4A-TETRAHYDROINDENO[1,2-B]PYRAZIN-2-ONE AND 1-BENZYL-4-TERT-BUTOXYCARBONYL-7-METHOXY-1,3,4,9-TETRAHYDROINDENO-[1,2-B]PYRAZIN-2-ONE

被引：11

作者：

PETERS, DA ^{[1
]}

BEDDOES, RL ^{[1
]}

JOULE, JA ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 11期

关键词：

D O I：

10.1039/p19930001217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Acetyl-3-(3-methoxybenzylidene)piperazine-2,5-dione 7a was converted via a 7-step sequence into 6-(3-methoxybenzyl)pyrazin-2(1H)-one 2a. Treatment of 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one 8a with acids results in cyclisation to indeno[1,2-b]pyrazin-2-ones, 9a, 9b or 11. The X-ray crystal structure determinations of 5-acetoxy-1-benzyl-4-tert-butoxycarbonyl-6-(3-methoxybenzylidene)piperazin-2-one, 8b, 1-benzyl-4-tert-butoxycarbonyl-7-methoxy-1,3,4,4a-tetrahydroindeno[1,2-b]pyrazin-2-one, 9b and 1-benzyl-4-tert-butoxycarbonyl-7-methoxy-1,3,4,9-tetrahydroindeno[1,2-b] pyrazin-2-one, 11 are described.

引用

页码：1217 / 1224

页数：8

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