Aromatic-aromatic interactions: analysis of pi-pi interactions in interleukins and TNF proteins

被引：13

作者：

Sivasakthi, Vaideeswaran ^{[1
]}

Anitha, Parimelzaghan ^{[1
]}

Kumar, Kalavathi Murugan ^{[1
]}

Bag, Susmita ^{[1
]}

Senthilvel, Padmanaban ^{[1
]}

Lavanya, Pandian ^{[1
]}

Swetha, Rayapadi ^{[1
]}

Anbarasu, Anand ^{[1
]}

Ramaiah, Sudha ^{[1
]}

机构：

[1] VIT Univ, Sch Biosci & Technol, Bioinformat Div, Vellore 632014, Tamil Nadu, India

来源：

BIOINFORMATION | 2013年 / 9卷 / 08期

关键词：

pi-pi interactions; TNF proteins; ILs; structure; stability; pi-network;

D O I：

10.6026/97320630009432

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aromatic-aromatic hydrogen bonds are important in many areas of chemistry, biology and materials science. In this study we have analyzed the roles played by the pi-pi interactions in interleukins (ILs) and tumor necrosis factor (TNF) proteins. Majority of pi-pi interacting residues are conserved in ILs and TNF proteins. The accessible surface area calculations in these proteins reveal that these interactions might be important in stabilizing the inner core regions of these proteins. In addition to pi-pi interactions, the aromatic residues also form pi-networks in ILs and TNF proteins. The results obtained in the present study indicate that pi-pi interactions and pi-pi networks play important roles in the structural stability of ILs and TNF proteins.

引用

页码：432 / 439

页数：8

共 50 条

[1] IMPACT OF LOCAL AND NONLOCAL INTERACTIONS ON THERMODYNAMICS AND KINETICS OF PROTEIN-FOLDING [J].

ABKEVICH, VI ;

GUTIN, AM ;

SHAKHNOVICH, EI .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 252 (04) :460-471

[2]

Alexandrakis MG, 1999, ANTICANCER RES, V19, P3607

[3]

Alexandrakis MG, 2000, ONCOL REP, V7, P1327

[4] Protein database searches using compositionally adjusted substitution matrices [J].

Altschul, SF ;

Wootton, JC ;

Gertz, EM ;

Agarwala, R ;

Morgulis, A ;

Schäffer, AA ;

Yu, YK .

FEBS JOURNAL, 2005, 272 (20) :5101-5109

[5] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[6]

Anand Sudha, 2008, In Silico Biology, V8, P261

[7] Exploring the role of cation-π interactions in glycoproteins lipid-binding proteins and RNA-binding proteins [J].

Anbarasu, Anand ;

Sethumadhavan, Rao .

JOURNAL OF THEORETICAL BIOLOGY, 2007, 247 (02) :346-353

[8] Computation of non-covalent interactions in TNF proteins and interleukins [J].

Anbarasu, Anand ;

Anand, Sudha ;

Mathew, Lazar ;

Rao, Sethumadhavan .

CYTOKINE, 2006, 35 (5-6) :263-269

[9]

ANTONY VB, 1993, J IMMUNOL, V151, P7216

[10] PLEURAL CELL BIOLOGY IN HEALTH AND DISEASE [J].

ANTONY, VB ;

SAHN, SA ;

MOSSMAN, B ;

GAIL, DB ;

KALICA, A .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (05) :1236-1239

← 1 2 3 4 5 →