2-HYDROXY-SACLOFEN - AN IMPROVED ANTAGONIST AT CENTRAL AND PERIPHERAL GABAB RECEPTORS

被引：209
作者：
KERR, DIB [1 ]
ONG, J [1 ]
JOHNSTON, GAR [1 ]
ABBENANTE, J [1 ]
PRAGER, RH [1 ]
机构：
[1] FLINDERS UNIV S AUSTRALIA,SCH PHYS SCI,BEDFORD PK,SA 5042,AUSTRALIA
来源：
NEUROSCIENCE LETTERS | 1988年 / 92卷 / 01期
关键词：
D O I：
10.1016/0304-3940(88)90748-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页码：92 / 96
页数：5
相关论文
共 11 条
[1]   GABA-A AND GABA-B RECEPTOR-SITE DISTRIBUTION IN THE RAT CENTRAL-NERVOUS-SYSTEM [J].
BOWERY, NG ;
HUDSON, AL ;
PRICE, GW .
NEUROSCIENCE, 1987, 20 (02) :365-383
[2]   THE SYNTHESIS OF PHOSPHONOBACLOFEN, AN ANTAGONIST OF BACLOFEN [J].
CHIEFARI, J ;
GALANOPOULOS, S ;
JANOWSKI, WK ;
KERR, DIB ;
PRAGER, RH .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1987, 40 (09) :1511-1518
[3]   A PHYSIOLOGICAL-ROLE FOR GABAB RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM [J].
DUTAR, P ;
NICOLL, RA .
NATURE, 1988, 332 (6160) :156-158
[4]   PERIPHERAL GABAERGIC MECHANISMS [J].
ERDO, SL .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1985, 6 (05) :205-208
[5]   HOMOTAURINE - A GABAB ANTAGONIST IN GUINEA-PIG ILEUM [J].
GIOTTI, A ;
LUZZI, S ;
SPAGNESI, S ;
ZILLETTI, L .
BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (04) :855-862
[6]   COMPARISON OF ANTAGONISM BY PHACLOFEN OF BACLOFEN INDUCED HYPERPOLARIZATIONS AND SYNAPTICALLY MEDIATED LATE HYPERPOLARIZING POTENTIALS RECORDED INTRACELLULARLY FROM RAT DORSOLATERAL SEPTAL NEURONS [J].
HASUO, H ;
GALLAGHER, JP .
NEUROSCIENCE LETTERS, 1988, 86 (01) :77-81
[7]   SPONTANEOUS PAROXYSMAL ACTIVITY INDUCED BY ZERO MAGNESIUM AND BICUCULLINE - SUPPRESSION BY NMDA ANTAGONISTS AND GABA MIMETICS [J].
HORNE, AL ;
HARRISON, NL ;
TURNER, JP ;
SIMMONDS, MA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 122 (02) :231-238
[8]   PHACLOFEN - A PERIPHERAL AND CENTRAL BACLOFEN ANTAGONIST [J].
KERR, DIB ;
ONG, J ;
PRAGER, RH ;
GYNTHER, BD ;
CURTIS, DR .
BRAIN RESEARCH, 1987, 405 (01) :150-154
[9]  
KERR DIB, 1988, NEUROSCIENCE LETT S, V30, pS85
[10]  
KERR DIB, 1986, P AUST PHYSL PHARM S, V17, pP114
12