SYNTHESIS AND CHARACTERIZATION OF O6-(2-CHLOROETHYL)GUANINE - A PUTATIVE INTERMEDIATE IN THE CYTOTOXIC REACTION OF CHLOROETHYLNITROSOUREAS WITH DNA

被引：20

作者：

PARKER, S

KIRK, MC

LUDLUM, DB

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT PHARMACOL,WORCESTER,MA 01655

[2] UNION UNIV ALBANY MED COLL,DEPT MED,DIV ONCOL,ALBANY,NY 12208

[3] SO RES INST,MOLEC SPECTROSCOPY SECT,BIRMINGHAM,AL 35255

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 148卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(87)80249-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1124 / 1128

页数：5

共 8 条

[1] SYNTHESIS OF POTENTIAL ANTICANCER AGENTS .25. PREPARATION OF 6-ALKOXY-2-AMINOPURINES [J].

BALSIGER, RW ;

MONTGOMERY, JA .

JOURNAL OF ORGANIC CHEMISTRY, 1960, 25 (09) :1573-1575

[2] EVIDENCE THAT O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BECOMES COVALENTLY BOUND TO DNA CONTAINING 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA-INDUCED PRECURSORS OF INTERSTRAND CROSS-LINKS [J].

BRENT, TP ;

SMITH, DG ;

REMACK, JS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (02) :341-347

[3] DNA CROSS-LINKING AND MONOADDUCT REPAIR IN NITROSOUREA-TREATED HUMAN-TUMOR CELLS [J].

ERICKSON, LC ;

LAURENT, G ;

SHARKEY, NA ;

KOHN, KW .

NATURE, 1980, 288 (5792) :727-729

[4]

Ludlum DB, 1986, IARC SCI PUBL, V70, P137

[5]

Montgomery J. A., 1981, NITROSOUREAS CURRENT, P3

[6] MECHANISM OF ACTION OF THE NITROSOUREAS .5. FORMATION OF O-6-(2-FLUOROETHYL) GUANINE AND ITS PROBABLE ROLE IN THE CROSSLINKING OF DEOXYRIBONUCLEIC-ACID [J].

TONG, WP ;

KIRK, MC ;

LUDLUM, DB .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (13) :2011-2015

[7]

TONG WP, 1982, CANCER RES, V42, P3102

[8] MOLECULAR PHARMACOLOGY OF THE HALOETHYL NITROSOUREAS - FORMATION OF 6-HYDROXYETHYLGUANINE IN DNA TREATED WITH BCNU (N,N1-BIS[2-CHLOROETHYL]-N-NITROSOUREA) [J].

TONG, WP ;

KIRK, MC ;

LUDLUM, DB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 100 (01) :351-357

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