EXPRESSION OF GALECTIN-1 IN NORMAL HUMAN THYROID-GLAND AND IN DIFFERENTIATED AND POORLY DIFFERENTIATED THYROID-TUMORS

被引：60
作者：
CHIARIOTTI, L
BERLINGIERI, MT
BATTAGLIA, C
BENVENUTO, G
MARTELLI, ML
SALVATORE, P
CHIAPPETTA, G
BRUNI, CB
FUSCO, A
机构：
[1] UNIV NAPLES FEDERICO II,FAC MED,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC,CNR,I-80131 NAPLES,ITALY
[2] UNIV REGGIO CALABRIA,DIPARTIMENTO MED SPERIMENTALE & CLIN,CATANZARO,ITALY
[3] IST NAZL TUMORI FDN PASCALE,NAPLES,ITALY
来源：
INTERNATIONAL JOURNAL OF CANCER | 1995年 / 64卷 / 03期
关键词：
D O I：
10.1002/ijc.2910640305
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We previously reported that galectin-1 gene expression increases up to 100-fold in oncogene-transformed rat thyroid cells compared with their normal counterparts and that the relative mRNA levels correlate with the degree of malignancy. In the present study we investigated whether galectin-1 is differentially expressed in human thyroid neoplasms, which range from well-differentiated tumors to undifferentiated anaplastic carcinomas. We analyzed 74 human thyroid specimens of neoplastic, hyperproliferative and normal tissues and several tumor cell lines. Galectin-1 mRNA and protein levels were higher in 6 thyroid carcinoma-derived cell lines than in normal thyroid primary cultures and adenoma cells. Galectin-1 mRNA levels increased in 28/40 papillary carcinomas and in 6/7 anaplastic carcinomas compared with normal or hyperplastic thyroid. Conversely, galectin-1 expression was unaffected in follicular carcinomas and benign adenomas. Immunohistochemical analysis of normal thyroid and papillary carcinoma sections revealed a higher content of galectin-1 protein in neoplastic follicular cells than in normal cells. (C) 1995 Wiley-Liss, Inc.
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页码：171 / 175
页数：5
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