MTB-PCDB: Mycobacterium tuberculosis proteome comparison database

被引：3
作者：
Jena, Lingaraja [1 ]
Wankhade, Gauri [1 ]
Kumar, Satish [1 ]
Harinath, Bhaskar Chinnaiah [1 ]
机构：
[1] Mahatma Gandhi Inst Med Sci, JB Trop Dis Res Ctr, Bioinformat Ctr, Wardha 442102, Maharashtra, India
来源：
BIOINFORMATION | 2011年 / 6卷 / 03期
关键词：
proteome comparison; tuberculosis; proteomic variation; virulence; drug resistance;
D O I：
10.6026/97320630006131
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Mycobacterium tuberculosis Proteome Comparison Database (MTB-PCDB) is an online database providing integrated access to proteome sequence comparison data for five strains of Mycobacterium tuberculosis (H37Rv, H37Ra, CDC 1551, F11 and KZN 1435) sequenced completely so far. MTB-PCDB currently hosts 40252 protein sequence comparison data obtained through inter-strain proteome comparison of five different strains of MTB. 2373 proteins were found to be identical in all 5 strains using MTB H37Rv as reference strain. To enable wide use of this data, MTB-PCDB provides a set of tools for searching, browsing, analyzing and downloading the data. By bringing together, M. tuberculosis proteome comparison among virulent & avirulent strains and also drug susceptible & drug resistance strains MTB-PCDB provides a unique discovery platform for comparative proteomics among these strains which may give insights into the discovery & development of TB drugs, vaccines and biomarkers.
引用
收藏
页码：131 / 133
页数：3
相关论文
共 7 条
[1]   BASIC LOCAL ALIGNMENT SEARCH TOOL [J].
ALTSCHUL, SF ;
GISH, W ;
MILLER, W ;
MYERS, EW ;
LIPMAN, DJ .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410
[2]   Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains [J].
Fleischmann, RD ;
Alland, D ;
Eisen, JA ;
Carpenter, L ;
White, O ;
Peterson, J ;
DeBoy, R ;
Dodson, R ;
Gwinn, M ;
Haft, D ;
Hickey, E ;
Kolonay, JF ;
Nelson, WC ;
Umayam, LA ;
Ermolaeva, M ;
Salzberg, SL ;
Delcher, A ;
Utterback, T ;
Weidman, J ;
Khouri, H ;
Gill, J ;
Mikula, A ;
Bishai, W ;
Jacobs, WR ;
Venter, JC ;
Fraser, CM .
JOURNAL OF BACTERIOLOGY, 2002, 184 (19) :5479-5490
[3]   Genome Analysis of Multi- and Extensively-Drug-Resistant Tuberculosis from KwaZulu-Natal, South Africa [J].
Ioerger, Thomas R. ;
Koo, Sunwoo ;
No, Eun-Gyu ;
Chen, Xiaohua ;
Larsen, Michelle H. ;
Jacobs, William R., Jr. ;
Pillay, Manormoney ;
Sturm, A. Willem ;
Sacchettini, James C. .
PLOS ONE, 2009, 4 (11)
[4]   GLOBAL EPIDEMIOLOGY OF TUBERCULOSIS - MORBIDITY AND MORTALITY OF A WORLDWIDE EPIDEMIC [J].
RAVIGLIONE, MC ;
SNIDER, DE ;
KOCHI, A .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (03) :220-226
[5]   TB database: an integrated platform for tuberculosis research [J].
Reddy, T. B. K. ;
Riley, Robert ;
Wymore, Farrell ;
Montgomery, Phillip ;
DeCaprio, Dave ;
Engels, Reinhard ;
Gellesch, Marcel ;
Hubble, Jeremy ;
Jen, Dennis ;
Jin, Heng ;
Koehrsen, Michael ;
Larson, Lisa ;
Mao, Maria ;
Nitzberg, Michael ;
Sisk, Peter ;
Stolte, Christian ;
Weiner, Brian ;
White, Jared ;
Zachariah, Zachariah K. ;
Sherlock, Gavin ;
Galagan, James E. ;
Ball, Catherine A. ;
Schoolnik, Gary K. .
NUCLEIC ACIDS RESEARCH, 2009, 37 :D499-D508
[6]   Worldwide emergence of extensively drug-resistant tuberculosis [J].
Shah, N. Sarita ;
Wright, Abigail ;
Bai, Gill-Han ;
Barrera, Lucia ;
Boulahbal, Fadila ;
Martin-Casabona, Nuria ;
Drobniewski, Francis ;
Gilpin, Chris ;
Havelkova, Marta ;
Lepe, Rosario ;
Lumb, Richard ;
Metchock, Beverly ;
Portaels, Francoise ;
Rodrigues, Maria Filomena ;
Ruesch-Gerdes, Sabine ;
Van Deun, Armand ;
Vincent, Veronique ;
Laserson, Kayla ;
Wells, Charles ;
Cegielski, J. Peter .
EMERGING INFECTIOUS DISEASES, 2007, 13 (03) :380-387
[7]   Genetic Basis of Virulence Attenuation Revealed by Comparative Genomic Analysis of Mycobacterium tuberculosis Strain H37Ra versus H37Rv [J].
Zheng, Huajun ;
Lu, Liangdong ;
Wang, Bofei ;
Pu, Shiying ;
Zhang, Xianglin ;
Zhu, Genfeng ;
Shi, Wanliang ;
Zhang, Lu ;
Wang, Honghai ;
Wang, Shengyue ;
Zhao, Guoping ;
Zhang, Ying .
PLOS ONE, 2008, 3 (06)
1