CD8+ CELL ANTI-HIV ACTIVITY CORRELATES WITH THE CLINICAL STATE OF THE INFECTED INDIVIDUAL

被引:292
作者
MACKEWICZ, CE [1 ]
ORTEGA, HW [1 ]
LEVY, JA [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO, SCH MED, CANC RES INST, DEPT MED, SAN FRANCISCO, CA 94143 USA
关键词
AIDS; HIV-1 INFECTED CELLS; CD4+ CELL NUMBER; CELL-MEDIATED IMMUNITY; CD8+ CELLS; PERIPHERAL BLOOD MONONUCLEAR CELLS;
D O I
10.1172/JCI115153
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The extent of antiviral activity exhibited in vitro by CD8+ lymphocytes from individuals infected by HIV-1 correlates significantly with their clinical status. CD8+ lymphocytes from asymptomatic subjects were found to inhibit HIV-1 replication by 90% or greater at effector/target (E/T) ratios ranging from as low as 0.05 to 0.25. CD8+ cells from 17 of 19 (89%) of these subjects suppressed replication at an E/T ratio of 0.10 or less. CD8+ lymphocytes from symptomatic patients (non-AIDS) inhibited HIV-1 replication at E/T ratios ranging from 0.05 to 1.0, and CD8+ cells from 8 of 13 (62%) required ratios > 0.10. As a group, patients with AIDS exhibited the lowest degree of anti-HIV activity with their CD8+ lymphocytes. The effective range of E/T ratios from AIDS patients was 0.10-2.0, and 9 of 10 (90%) required E/T ratios > 0.25. This anti-HIV activity exhibited by CD8+ cells also correlated significantly with the subject's peripheral blood CD4+ cell count. The relative extent of CD8+ cell anti-HIV-1 activity was not found dependent on variations in the CD4+ target cells and viruses used. These findings suggest that the decreased CD8+ cell antiviral activity is related to progression to disease in HIV-infected individuals.
引用
收藏
页码:1462 / 1466
页数:5
相关论文
共 33 条
[1]  
BONAVIDA B, 1986, J IMMUNOL, V137, P1157
[2]  
BRINCHMANN JE, 1990, J IMMUNOL, V144, P2961
[3]   BIOLOGIC FEATURES OF HIV-1 THAT CORRELATE WITH VIRULENCE IN THE HOST [J].
CHENGMAYER, C ;
SETO, D ;
TATENO, M ;
LEVY, JA .
SCIENCE, 1988, 240 (4848) :80-82
[4]   EVALUATION OF NATURAL-KILLER CELL-ACTIVITY IN PATIENTS WITH PERSISTENT GENERALIZED LYMPHADENOPATHY AND ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
CREEMERS, PC ;
STARK, DF ;
BOYKO, WJ .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1985, 36 (02) :141-150
[5]  
ENGERS HD, 1984, J IMMUNOL, V133, P1664
[6]   ANTIBODY-DEPENDENT CELLULAR CYTO-TOXICITY IS DIRECTED AGAINST BOTH THE GP120 AND GP41 ENVELOPE PROTEINS OF HIV [J].
EVANS, LA ;
THOMSONHONNEBIER, G ;
STEIMER, K ;
PAOLETTI, E ;
PERKUS, ME ;
HOLLANDER, H ;
LEVY, JA .
AIDS, 1989, 3 (05) :273-276
[7]   T-CELL SUBSET ALTERATIONS IN HIV-INFECTED HOMOSEXUAL MEN - NIAID MULTICENTER AIDS COHORT STUDY [J].
GIORGI, JV ;
DETELS, R .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1989, 52 (01) :10-18
[8]  
GLUCKMAN JC, 1985, CLIN EXP IMMUNOL, V60, P8
[9]   HUMAN IMMUNODEFICIENCY VIRUS-RELATED LYMPHOCYTIC ALVEOLITIS [J].
GUILLON, JM ;
AUTRAN, B ;
DENIS, M ;
FOURET, P ;
PLATA, F ;
MAYAUD, CM ;
AKOUN, GM .
CHEST, 1988, 94 (06) :1264-1270
[10]   CD4+ LYMPHOCYTE FUNCTION WITH EARLY HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
GURLEY, RJ ;
IKEUCHI, K ;
BYRN, RA ;
ANDERSON, K ;
GROOPMAN, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :1993-1997