THE APPEARANCE OF NEUTRAL LIPID SIGNALS IN THE H-1-NMR SPECTRA OF A MYELOMA CELL-LINE CORRELATES WITH THE INDUCED FORMATION OF CYTOPLASMIC LIPID DROPLETS

被引：105

作者：

CALLIES, R

SRIPATHMANATHAN, RM

FERGUSON, DYP

BRINDLE, KM

机构：

[1] UNIV MANCHESTER,DEPT BIOCHEM & MOLEC BIOL,OXFORD RD,MANCHESTER M13 9PT,LANCS,ENGLAND

[2] UNIV OXFORD,JOHN RADCLIFFE HOSP,DEPT PATHOL & BACTERIOL,OXFORD OX3 9DU,ENGLAND

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 29卷 / 04期

关键词：

LIPIDS; DROPLETS; CELLS; NMR;

D O I：

10.1002/mrm.1910290418

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The appearance of high resolution neutral lipid signals in the H-1 NMR spectra of myeloma cells grown in the presence of oleate was shown to correlate with the appearance of cytoplasmic lipid droplets observable by electron microscopy. The spin-spin relaxation times of these lipid signals were similar to those measured previously for lipid resonances in other cell types. These data suggest that cytoplasmic lipid droplets could make a significant contribution to the neutral lipid signals observed in the H-1 NMR spectra of some cells.

引用

页码：546 / 550

页数：5

共 25 条

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Brindle K. M., 1984, BIOMEDICAL MAGNETIC, P243

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