Postoperative Radiotherapy for Squamous Cell Carcinoma of the Head and Neck

被引：38

作者：

Mendenhall, William M. ^{[1
]}

Hinerman, Russell W. ^{[1
]}

Amdur, Robert J. ^{[1
]}

Malyapa, Robert S. ^{[1
]}

Lansford, Christopher D. ^{[2
]}

Werning, John W. ^{[2
]}

Villaret, Douglas B. ^{[2
]}

机构：

[1] Univ Florida, Coll Med, Dept Radiat Oncol, Gainesville, FL USA

[2] Univ Florida, Coll Med, Dept Otolaryngol, Gainesville, FL USA

来源：

CLINICAL MEDICINE & RESEARCH | 2006年 / 4卷 / 03期

关键词：

Head and neck; Radiotherapy; Squamous cell carcinoma;

D O I：

10.3121/cmr.4.3.200

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review discusses the role of postoperative radiotherapy (RT) for patients with squamous cell carcinoma of the head and neck. Patients with unfavorable pathologic features have a high-risk of local-regional recurrence and a decreased likelihood of survival after surgery alone. Postoperative RT reduces the risk of local-regional failure and probably improves survival. Patients who are at high risk for recurrence may benefit from more aggressive altered fractionation schedules to decrease the overall time from surgery to the completion of RT. Adjuvant cisplatin-based chemotherapy also appears to improve the probability of cure in high-risk patients.

引用

页码：200 / 208

页数：9

共 42 条

[1]

Adelstein DJ, 2000, CANCER, V88, P876, DOI 10.1002/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO

[2]

2-Y

[3]

*AM JOINT COMM CAN, 1997, AJCC CANC STAG MAN, P21

[4] SPLIT-COURSE VERSUS CONTINUOUS-COURSE IRRADIATION IN THE POSTOPERATIVE SETTING FOR SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK [J].

AMDUR, RJ ;

PARSONS, JT ;

MENDENHALL, WM ;

MILLION, RR ;

CASSISI, NJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1989, 17 (02) :279-285

[5] POSTOPERATIVE IRRADIATION FOR SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK - AN ANALYSIS OF TREATMENT RESULTS AND COMPLICATIONS [J].

AMDUR, RJ ;

PARSONS, JT ;

MENDENHALL, WM ;

MILLION, RR ;

STRINGER, SP ;

CASSISI, NJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1989, 16 (01) :25-36

[6] Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer [J].

Ang, KK ;

Trotti, A ;

Brown, BW ;

Garden, AS ;

Foote, RL ;

Morrison, WH ;

Geara, FB ;

Klotch, DW ;

Goepfert, H ;

Peters, LJ .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (03) :571-578

[7] The influence of beam energy on the outcome of postoperative radiotherapy in head and neck cancer patients: Secondary analysis of RTOG 85-03 [J].

Aref, A ;

Berkey, BA ;

Schwade, JG ;

Ensley, J ;

Schuller, DE ;

Haselow, RE ;

Ervin, TJ ;

Laramore, GE .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 47 (02) :389-394

[8] Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: Final report of a randomized trial [J].

Bachaud, JM ;

CohenJonathan, E ;

Alzieu, C ;

David, JM ;

Serrano, E ;

DalySchveitzer, N .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 36 (05) :999-1004

[9] Influence of the delay of adjuvant postoperative radiation therapy on relapse and survival in oropharyngeal and hypopharyngeal cancers [J].

Bastit, L ;

Blot, E ;

Debourdeau, P ;

Menard, JF ;

Bastit, P ;

Le Fur, R .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (01) :139-146

[10] Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer [J].

Bernier, J ;

Domenge, C ;

Ozsahin, M ;

Matuszewska, K ;

Lefèbvre, JL ;

Greiner, RH ;

Giralt, J ;

Maingon, P ;

Rolland, F ;

Bolla, M ;

Cognetti, F ;

Bourhis, J ;

Kirkpatrick, A ;

van Glabbeke, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (19) :1945-1952

← 1 2 3 4 5 →