SYNTHESIS OF GLYCURONAMIDES OF AMINO-ACIDS, CONSTITUENTS OF MICROBIAL POLYSACCHARIDES AND THEIR CONVERSION INTO NEOGLYCOCONJUGATES OF COPOLYMER TYPE

被引：20

作者：

CHERNYAK, AY ^{[1
]}

SHARMA, GVM ^{[1
]}

KONONOV, LO ^{[1
]}

KRISHNA, PR ^{[1
]}

RAO, AVR ^{[1
]}

KOCHETKOV, NK ^{[1
]}

机构：

[1] INDIAN INST CHEM TECHNOL,HYDERABAD 500007,INDIA

来源：

GLYCOCONJUGATE JOURNAL | 1991年 / 8卷 / 02期

关键词：

AMINO ACID-GLYCURONAMIDES; SYNTHESIS; NEOGLYCOCONJUGATES;

D O I：

10.1007/BF00731016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycopyranosiduronic acids, amidically linked to amino acids (alanine, serine, threonine, and lysine) were prepared. O-tert-Butyl and N-epsilon-tert-butyloxycarbonyl protected amino acid tert-butyl esters were used in ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate promoted condensation with 2-azidoethyl glycosides of glucuronic and galacturonic acid. Reduction of the azido-function followed by N-acryloylation and removal of blocking groups with trifluoroacetic acid gave the target monomers. These were converted into neoglycoconjugates of copolymer type, potentially useful for immunochemical studies.

引用

页码：82 / 89

页数：8

共 27 条

[1] PREPARATION, PROPERTIES, AND APPLICATIONS OF CARBOHYDRATE CONJUGATES OF PROTEINS AND LIPIDS [J].