OPIATE ANTAGONIST, NALOXONE, DOES NOT AFFECT DESCENDING INHIBITION FROM MIDBRAIN OF NOCICEPTIVE SPINAL NEURONAL DISCHARGES IN THE CAT

被引：40

作者：

CARSTENS, E

KLUMPP, D

ZIMMERMANN, M

机构：

[1] II. Physiologisches Institut der Universität, Heidelberg

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1016/0304-3940(79)90016-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Discharges were recorded from spinal dorsal horn neurons in response to noxious skin heating (e.g. 50°C). Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges. In each of 9 experiments systemic administration of naloxone (1-3 mg/kg) did not affect this descending inhibition, arguing against involvement of endogenous opiates. © 1979.

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页码：323 / 327

页数：5

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