DOSE-DEPENDENT EFFECTS OF ZINC SUPPLEMENTATION DURING CHELATION OF LEAD IN RATS

被引：12
作者：
FLORA, SJS
BHATTACHARYA, R
SACHAN, SRS
机构：
[1] Defence Research and Development Establishment, Division of Pharmacology and Toxicology, Gwalior, 474 002, Tansen Road
来源：
PHARMACOLOGY & TOXICOLOGY | 1994年 / 74卷 / 06期
关键词：
D O I：
10.1111/j.1600-0773.1994.tb01368.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dose-dependent effects of zinc supplementation in order to enhance the efficacy of calcium disodium EDTA in lead intoxicated rats was investigated in rats. The results suggest simultaneous supplementation of zinc at a lower concentration i.e. 10 mg/kg (orally, once during chelation treatment), 25 mg/kg zinc (Flora & Tandon 1990) potentiates the mobilization of lead from blood and soft tissues. However, at a higher dose level (50 mg/kg once orally) it has deleterious and much reduced ability to deplete tissue lead contents and restore altered lead sensitive biochemical variables.
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页码：330 / 333
页数：4
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