EFFECTS OF ANTIEPILEPTIC DRUGS ON THE L-TRYPTOPHAN BINDING TO HUMAN SERUM-ALBUMIN

被引：0
|
作者：
HIRAOKA, A
MIURA, I
SATO, M
TOMINAGA, I
HATTORI, M
机构：
[1] TOKYO METROPOLITAN UNIV, FAC SCI, DEPT BIOL, HACHIOJI, TOKYO 19203, JAPAN
[2] CHIBA NATL HOSP, DEPT NEUROPSYCHIAT, CHIBA 260, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 06期
关键词：
L-TRYPTOPHAN; HUMAN SERUM ALBUMIN; ANTIEPILEPTIC DRUG; SODIUM VALPROATE; BINDING INHIBITION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Effects of four anti-epileptic drugs (AED; phenobarbital, phenytoin, carbamazepine and sodium valproate) on the L-tryptophan binding to human serum albumin were studied. Among these drugs examined, only sodium valproate inhibited the binding even within the concentrations of its therapeutic range, and the Klotz plotting analysis revealed that the inhibition was competitive. The results of examinations with sera from epileptic patients medicated with these AED and drug-free normal controls also suggested that the protein binding ratios of L-tryptophan were decreased in the blood plasma of some patients with the high valproate concentrations and the low albumin contents.
引用
收藏
页码：1629 / 1630
页数：2
相关论文
共 50 条
12345