HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION OF CELLS ARRESTED IN THE CELL-CYCLE

被引:400
作者
LEWIS, P
HENSEL, M
EMERMAN, M
机构
[1] FRED HUTCHINSON CANC RES CTR,DIV BASIC SCI,SEATTLE,WA 98104
[2] FRED HUTCHINSON CANC RES CTR,PROGRAM MOLEC MED,SEATTLE,WA 98104
关键词
AIDS; CELL CYCLE; HIV; MACROPHAGES; MULV;
D O I
10.1002/j.1460-2075.1992.tb05376.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell proliferation is necessary for proviral integration and productive infection of most retroviruses. Nevertheless, the human immunodeficiency virus (HIV) can infect non-dividing macrophages. This ability to grow in non-dividing cells is not specific to macrophages because, as we show here, CD4+ HeLa cells arrested at stage G2 Of the cell cycle can be infected by HIV-1. Proliferation is necessary for these same cells to be infected by a murine retrovirus, MuLV. HIV-1 integrates into the arrested cell DNA and produces viral RNA and protein in a pattern similar to that in normal cells. In addition, our data suggest that the ability to infect non-dividing cells is due to one of the HIV-1 core virion proteins. HIV infection of non-dividing cells distinguishes lentiviruses from other retroviruses and is likely to be important in the natural history of HIV infection.
引用
收藏
页码:3053 / 3058
页数:6
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