THE EFFECT OF INSULIN-LIKE GROWTH FACTOR-II ON GLUCOSE-UPTAKE AND METABOLISM IN RAT SKELETAL-MUSCLE INVITRO

被引：10

作者：

BEVAN, SJ ^{[1
]}

PARRYBILLINGS, M ^{[1
]}

OPARA, E ^{[1
]}

LIU, CT ^{[1
]}

DUNGER, DB ^{[1
]}

NEWSHOLME, EA ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT PEDIAT,OXFORD,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1992年 / 286卷

关键词：

D O I：

10.1042/bj2860561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of insulin-like growth factor II (IGF II) on the rates of lactate formation, glycogen synthesis and glucose transport in the presence of a range of concentrations of insulin were investigated using an isolated preparation of rat skeletal muscle. IGF II, at a concentration of 65 ng/ml, caused a small but significant increase in the rates of these processes at a basal physiological insulin concentration (10-mu-units/ml), but was without effect in the presence of 1,100, 1000 or 10000-mu-units of insulin/ml. Hence IGF II increased the insulin sensitivity of this tissue. This effect was removed if the incubation medium was supplemented with an equimolar concentration of IGF binding protein 1 (BP1). It is suggested that changes in the concentration of IGF II and/or BP1 may regulate glucose uptake and metabolism in skeletal muscle and have physiological significance in the control of blood glucose level.

引用

页码：561 / 565

页数：5

共 36 条

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