SYNTHESIS OF 2'-DEOXYNUCLEOSID-3'-YL-N,N-DIISOPROPYLAMINOPHOSPHORFLUORIDITES - A NEW CLASS OF STABLE P(III) NUCLEOTIDES CONTAINING A P-F BOND

被引：24

作者：

DABKOWSKI, W

TWOROWSKA, I

机构：

[1] Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences, 90-363 Łódź

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02403-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology based on phosphitylating reagents containing 4-nitrophenoxy leaving group has been employed to synthesize stable 5'-O-(4,4'-dimethoxytrityl)nucleosid-3'-yl-N,N-diisopropylaminophosphorfluoridites Ia-d.

引用

页码：1095 / 1098

页数：4

共 4 条

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DABKOWSKI, W ;

CRAMER, F ;

MICHALSKI, J .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (11) :1447-1452

[2] NEW GENERAL-SYNTHESIS OF ORGANOPHOSPHORUS P-F COMPOUNDS VIA REACTION OF AZOLIDES OF PHOSPHORUS-ACIDS WITH ACYL FLUORIDES - NOVEL ROUTE TO 2-DEOXYNUCLEOSIDYL PHOSPHOROFLUORIDATES AND PHOSPHORODIFLUORIDATES [J].

DABKOWSKI, W ;

MICHALSKI, J ;

WASIAK, J ;

CRAMER, F .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (07) :817-820

[3] NEW PHOSPHITYLATING REAGENT IN THE NUCLEOTIDE CHEMISTRY CONTAINING 2 4-NITROPHENOXY LEAVING GROUPS - REMARKABLY FAST AND CLEAN PHOSPHITYLATIONS ACTIVATED BY DBU LEADING TO THIO-OLIGONUCLEOTIDES AND SELENO-OLIGONUCLEOTIDES [J].

HELINSKI, J ;

DABKOWSKI, W ;

MICHALSKI, J .

TETRAHEDRON LETTERS, 1993, 34 (40) :6451-6454

[4]

UHLMANN E, 1990, CHEM REV, V90, P563

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