QUANTITATIVE MICRODIALYSIS DETERMINATION OF EXTRACELLULAR STRIATAL DOPAMINE CONCENTRATION IN MALE AND FEMALE RATS - EFFECTS OF ESTROUS-CYCLE AND GONADECTOMY

被引：180
作者：
XIAO, L
BECKER, JB
机构：
[1] UNIV MICHIGAN,DEPT PSYCHOL,ANN ARBOR,MI
[2] UNIV MICHIGAN,REPROD SCI PROGRAM,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109
来源：
NEUROSCIENCE LETTERS | 1994年 / 180卷 / 02期
基金：
美国国家科学基金会;
关键词：
ESTROUS CYCLE; OVARIECTOMY; CASTRATION; OVARIAN HORMONE; EXTRACELLULAR STRIATAL DOPAMINE; QUANTITATIVE MICRODIALYSIS;
D O I：
10.1016/0304-3940(94)90510-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sex differences in basal extracellular striatal dopamine concentrations in gonadectomized male and female rats have been reported previously. In the current experiment, estrous cycle-dependent variation, sex differences and the effect of gonadectomy on extracellular striatal dopamine concentrations were determined using quantitative microdialysis. Female rats were found to have significantly higher extracellular striatal dopamine concentrations in proestrus and estrus than in diestrus or after ovariectomy. In contrast, castration of male rats had no effect on extracellular striatal dopamine concentrations. Thus, endogenous ovarian hormones, but not testicular hormones, modulate extracellular striatal dopamine concentrations in rats.
引用
收藏
页码：155 / 158
页数：4
相关论文
共 18 条
[1]   THE INFLUENCE OF ESTROUS-CYCLE AND INTRASTRIATAL ESTRADIOL ON SENSORIMOTOR PERFORMANCE IN THE FEMALE RAT [J].
BECKER, JB ;
SNYDER, PJ ;
MILLER, MM ;
WESTGATE, SA ;
JENUWINE, MJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (01) :53-59
[2]   SEX-DIFFERENCES IN THE AMPHETAMINE STIMULATED RELEASE OF CATECHOLAMINES FROM RAT STRIATAL TISSUE INVITRO [J].
BECKER, JB ;
RAMIREZ, VD .
BRAIN RESEARCH, 1981, 204 (02) :361-372
[3]   ESTROGEN RAPIDLY POTENTIATES AMPHETAMINE-INDUCED STRIATAL DOPAMINE RELEASE AND ROTATIONAL BEHAVIOR DURING MICRODIALYSIS [J].
BECKER, JB .
NEUROSCIENCE LETTERS, 1990, 118 (02) :169-171
[4]   THE INFLUENCE OF ESTROGEN ON NIGROSTRIATAL DOPAMINE ACTIVITY - BEHAVIORAL AND NEUROCHEMICAL EVIDENCE FOR BOTH PRE-NAPTIC AND POSTSYNAPTIC COMPONENTS [J].
BECKER, JB ;
BEER, ME .
BEHAVIOURAL BRAIN RESEARCH, 1986, 19 (01) :27-33
[5]   ESTROUS CYCLE-DEPENDENT VARIATION IN AMPHETAMINE-INDUCED BEHAVIORS AND STRIATAL DOPAMINE RELEASE ASSESSED WITH MICRODIALYSIS [J].
BECKER, JB ;
CHA, JH .
BEHAVIOURAL BRAIN RESEARCH, 1989, 35 (02) :117-125
[6]   SEX-DIFFERENCES AND ESTROUS-CYCLE VARIATIONS IN AMPHETAMINE-ELICITED ROTATIONAL BEHAVIOR [J].
BECKER, JB ;
ROBINSON, TE ;
LORENZ, KA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 80 (01) :65-72
[7]   EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF SEX-DIFFERENCES IN THE RELEASE OF DOPAMINE FROM STRIATAL TISSUE FRAGMENTS INVITRO [J].
BECKER, JB ;
RAMIREZ, VD .
NEUROENDOCRINOLOGY, 1981, 32 (03) :168-173
[8]   STRIATAL DOPAMINE RELEASE STIMULATED BY AMPHETAMINE OR POTASSIUM - INFLUENCE OF OVARIAN HORMONES AND THE LIGHT-DARK CYCLE [J].
BECKER, JB ;
BEER, ME ;
ROBINSON, TE .
BRAIN RESEARCH, 1984, 311 (01) :157-160
[9]   SEX-DIFFERENCES IN THE EFFECTS OF GONADECTOMY ON AMPHETAMINE-INDUCED ROTATIONAL BEHAVIOR IN RATS [J].
CAMP, DM ;
BECKER, JB ;
ROBINSON, TE .
BEHAVIORAL AND NEURAL BIOLOGY, 1986, 46 (03) :491-495
[10]   SEX-DIFFERENCES IN STRIATAL DOPAMINE - INVIVO MICRODIALYSIS AND BEHAVIORAL-STUDIES [J].
CASTNER, SA ;
XIAO, L ;
BECKER, JB .
BRAIN RESEARCH, 1993, 610 (01) :127-134
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