COMMON SPATIAL ARRANGEMENTS OF BACKBONE FRAGMENTS IN HOMOLOGOUS AND NONHOMOLOGOUS PROTEINS

被引：86

作者：

ALEXANDROV, NN ^{[1
]}

TAKAHASHI, K ^{[1
]}

GO, N ^{[1
]}

机构：

[1] KYOTO UNIV,FAC SCI,DEPT CHEM,KYOTO 606,JAPAN

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1992年 / 225卷 / 01期

基金：

日本学术振兴会;

关键词：

PROTEIN STRUCTURE; STRUCTURAL SIMILARITY; ENDOTHIAPEPSIN;

D O I：

10.1016/0022-2836(92)91021-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed a new method of detecting common spatial arrangements of backbone fragments in proteins. This method allows corresponding fragments to occur in a different order in respective amino acid sequences. We applied this method to detect structural similarities between an acid protease, endothiapepsin, and all other proteins in the protein data bank. Significant similarities were found not only with other acid proteases but also with virus proteases and with proteins having different functions. The possible biological meaning of these similarities is discussed. © 1992.

引用

页码：5 / 9

页数：5

共 15 条

[1] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].