REVERSAL OF EXPERIMENTAL HEMORRHAGIC-SHOCK BY DIMETHYLPHENYLPIPERAZINIUM (DMPP)

被引：7
作者：
GUARINI, S
BAZZANI, C
TAGLIAVINI, S
BERTOLINI, A
FERRARI, W
机构：
[1] Institute of Pharmacology, University of Modena, Modena, I-41100
来源：
EXPERIENTIA | 1992年 / 48卷 / 07期
关键词：
HYPOVOLEMIC SHOCK; HEMORRHAGE; DIMETHYLPHENYLPIPERAZINIUM; RESUSCITATION;
D O I：
10.1007/BF02118314
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition - without the need for reinfusion of the shed blood - starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
引用
收藏
页码：663 / 667
页数：5
相关论文
共 30 条
[11]  
BLAHITKA J, 1977, CIRC SHOCK, V4, P79
[12]  
DOWNIE HG, 1955, CAN J BIOCHEM PHYS, V33, P436
[13]   EARLY TREATMENT WITH ACTH-(1-24) IN A RAT MODEL OF HEMORRHAGIC-SHOCK PROLONGS SURVIVAL AND EXTENDS THE TIME-LIMIT FOR BLOOD REINFUSION TO BE EFFECTIVE [J].
GUARINI, S ;
TAGLIAVINI, S ;
BAZZANI, C ;
FERRARI, W ;
BERTOLINI, A .
CRITICAL CARE MEDICINE, 1990, 18 (08) :862-865
[14]   NICOTINE REVERSES HEMORRHAGIC-SHOCK IN RATS [J].
GUARINI, S ;
TAGLIAVINI, S ;
BAZZANI, C ;
BERTOLINI, A ;
FERRARI, W .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1991, 343 (04) :427-430
[15]  
GUARINI S, 1988, N-S ARCH PHARMACOL, V337, P556
[16]  
GUARINI S, 1990, N-S ARCH PHARMACOL, V342, P36
[17]   INFLUENCE OF VAGOTOMY AND OF ATROPINE ON THE ANTI-SHOCK EFFECT OF ADRENOCORTICOTROPIN [J].
GUARINI, S ;
ROMPIANESI, E ;
FERRARI, W ;
BERTOLINI, A .
NEUROPEPTIDES, 1986, 8 (01) :19-24
[18]   ANTI-SHOCK EFFECT OF ACTH-(1-24) - INFLUENCE OF SUBTOTAL HEPATECTOMY [J].
GUARINI, S ;
FERRARI, W ;
BERTOLINI, A .
PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1988, 20 (05) :395-403
[19]   EFFECT OF ACTH-(1-24) ON THE VOLUME OF CIRCULATING BLOOD AND ON REGIONAL BLOOD-FLOW IN RATS BLED TO HYPOVOLEMIC SHOCK [J].
GUARINI, S ;
TAGLIAVINI, S ;
BAZZANI, C ;
BENELLI, A ;
BERTOLINI, A ;
FERRARI, W .
RESUSCITATION, 1989, 18 (2-3) :133-134
[20]  
GUARINI S, 1987, ARCH INT PHARMACOD T, V289, P311
123