REVERSAL OF EXPERIMENTAL HEMORRHAGIC-SHOCK BY DIMETHYLPHENYLPIPERAZINIUM (DMPP)

被引：7
作者：
GUARINI, S
BAZZANI, C
TAGLIAVINI, S
BERTOLINI, A
FERRARI, W
机构：
[1] Institute of Pharmacology, University of Modena, Modena, I-41100
来源：
EXPERIENTIA | 1992年 / 48卷 / 07期
关键词：
HYPOVOLEMIC SHOCK; HEMORRHAGE; DIMETHYLPHENYLPIPERAZINIUM; RESUSCITATION;
D O I：
10.1007/BF02118314
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition - without the need for reinfusion of the shed blood - starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
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收藏
页码：663 / 667
页数：5
相关论文
共 30 条
[1]  
BADANNE M, 1983, J NEUROPATH EXP NEUR, V42, P561
[2]   EPIDEMIOLOGY OF TRAUMA - THE CIVILIAN PERSPECTIVE [J].
BAKER, CC .
ANNALS OF EMERGENCY MEDICINE, 1986, 15 (12) :1389-1391
[3]   EPIDEMIOLOGY OF TRAUMA - MILITARY EXPERIENCE [J].
BELLAMY, RF ;
MANINGAS, PA ;
VAYER, JS .
ANNALS OF EMERGENCY MEDICINE, 1986, 15 (12) :1384-1388
[4]  
BELLAMY RF, 1984, MIL MED, V149, P55
[5]   CIRCULATORY AND RESPIRATORY CONSEQUENCES OF MASSIVE HEMORRHAGE ARE REVERSED BY PROTOVERATRINES [J].
BERTOLINI, A ;
FERRARI, W ;
GUARINI, S ;
TAGLIAVINI, S .
EXPERIENTIA, 1990, 46 (07) :704-708
[6]   ADRENOCORTICOTROPIN REVERSAL OF EXPERIMENTAL HEMORRHAGIC-SHOCK IS ANTAGONIZED BY MORPHINE [J].
BERTOLINI, A ;
GUARINI, S ;
FERRARI, W ;
ROMPIANESI, E .
LIFE SCIENCES, 1986, 39 (14) :1271-1280
[7]   ALPHA-MSH AND OTHER ACTH FRAGMENTS IMPROVE CARDIOVASCULAR FUNCTION AND SURVIVAL IN EXPERIMENTAL HEMORRHAGIC-SHOCK [J].
BERTOLINI, A ;
GUARINI, S ;
ROMPIANESI, E ;
FERRARI, W .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 130 (1-2) :19-26
[8]   ADRENAL-INDEPENDENT, ANTI-SHOCK EFFECT OF ACTH-(1-24) IN RATS [J].
BERTOLINI, A ;
GUARINI, S ;
FERRARI, W .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 122 (03) :387-388
[9]   THE ADRENOCORTICOTROPIC HORMONE (ACTH)-INDUCED REVERSAL OF HEMORRHAGIC-SHOCK [J].
BERTOLINI, A ;
FERRARI, W ;
GUARINI, S .
RESUSCITATION, 1989, 18 (2-3) :253-267
[10]   ACTH-(1-24) RESTORES BLOOD-PRESSURE IN ACUTE HYPOVOLEMIA AND HEMORRHAGIC-SHOCK IN HUMANS [J].
BERTOLINI, A ;
GUARINI, S ;
FERRARI, W ;
NOERA, G ;
MASSINI, C ;
DITIZIO, S .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 32 (05) :537-538
123