SUSCEPTIBILITY OF MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I-DEFICIENT AND MHC CLASS II-DEFICIENT MICE TO CRYPTOSPORIDIUM-PARVUM INFECTION

被引：84

作者：

AGUIRRE, SA ^{[1
]}

MASON, PH ^{[1
]}

PERRYMAN, LE ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV,DEPT VET MICROBIOL & PATHOL,PULLMAN,WA 99164

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 02期

关键词：

D O I：

10.1128/IAI.62.2.697-699.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Major histocompatibility complex (MHC) class I-deficient and MHC class II-deficient mice lack functional CD8 T cells and CD4 T cells, respectively. These mice were evaluated for infection following oral administration of 10(7) Cryptosporidium parvum oocysts. MHC class II-deficient (but not MHC class I-deficient) mice dosed with C. parvum oocysts at 3 to 5 days of age remained infected 8 weeks postexposure. MHC class II-deficient mice exposed to C. parvum oocysts at 5 to 6 weeks of age were significantly more susceptible to infection than control mice (P < 0.0001).

引用

页码：697 / 699

页数：3

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