Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay

被引：6

作者：

Shiraishi, Fujio ^{[1
]}

Kamata, Ryo ^{[2
]}

Terasaki, Masanori ^{[3
]}

Takigami, Hidetaka ^{[1
]}

Imaizumi, Yoshitaka ^{[1
]}

Yagishita, Mayuko ^{[1
]}

Nakajima, Daisuke ^{[1
]}

机构：

[1] Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan

[2] Kitasato Univ, 23-35-1 Higashi, Towada, Aomori 0348628, Japan

[3] Iwate Univ, 3-18-8 Ueda, Morioka, Iwate 0208550, Japan

来源：

DATA IN BRIEF | 2018年 / 21卷

关键词：

D O I：

10.1016/j.dib.2018.11.071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：2543 / 2546

页数：4

共 4 条

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[4]

Shiraishi F, 2000, KANKYO KAGAKU, V10, P57, DOI [10.5985/jec.10.57, DOI 10.5985/JEC.10.57]

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